Rubidomycin - Softcover

Inhaltsangabe

History of Rubidomycin.- The First Antimitotic Antibiotics.- Isolation of Rubidomycin.- The First Clinical Trials.- The First Overall Surveys.- I - Preparation and Experimental Investigation.- 1: Preparation.- 1. Production.- a) Productive Strains.- b) Production in Fermenters.- 2. Isolation.- a) Extraction of the Crude Base.- b) Fractionation by Counter-current Distribution.- 3. Analytical Methods.- 4. Physicochemical Properties.- a) Solubility.- b) Stability.- c) Properties.- d) Comparison of Rubidomycin and Rubomycin C on the Basis of their Physicochemical Properties.- 5. Tritiated Rubidomycin.- a) Preparation.- b) Analytical Results.- 2: Structure.- 3: Biological Activity.- 1. Cytostatic Activity and Cell Changes.- a) KB and HeLa Cells.- ?) Cytostatic Activity.- ?) Cell Changes.- b) Ehrlich Ascites Cells.- ?) Cytostatic Activity.- ?) Cell Changes.- c) Plant Cells.- 2. Antitumor Activity in Animals.- a) Tumors of Mice.- ?) Carcinomas.- ?) Ehrlich Ascites Tumor.- ?) Sarcomas.- ?) Leukoses and Leukosarcomatosis.- b) Tumors and Leukemia of Viral Etiology.- ?) Avian Sarcomas.- ?) Shope Fibroma.- ?) Rauscher Leukemia.- 3. Immunodepressive Activity.- a) Effect on the Production of Antibodies.- b) Action on Immunologically Active Spleen Cells.- c) Action on Grafts.- d) Action on the Lymphoblastic Transformation of Lymphocytes in vitro.- 4. Antibacterial Activity.- 5. General Pharmacological Properties.- a) Effect on the Cardiovascular System.- ?) Effect on the Arterial Pressure.- ?) Effect on the Heart.- b) Effect on Respiration.- c) Effect on the Sympathetic Nervous System.- 4: Fixation in the Cell and Mechanism of Action.- 1. Fixation in the Cell.- a) Autoradiography of KB Cells.- b) Measurement of the Tritiated Rubidomycin in Normal Hepatic Cells.- c) Fluorescent Microscopy (KB Cells).- 2. Mechanism of Action.- a) Action on Energy Metabolism.- ?) Method of Study.- ?) Results.- b) Action on Protein Synthesis.- ?) Method of Study.- ?) Results.- c) Action on the Synthesis of Nucleic Acids.- ?) Staining of the Cells with Acridine Orange.- ?) Autoradiographic Study of the Incorporation of Tritiated Thymidine and Uridine into the Treated Cells.- ?) Determination by Measurement of the Incorporation of Tritiated Thymidine and Uridine in the Nucleic Acids of Ehrlich Ascitic Tumor Cells.- 5: Toxicology.- 1. Acute Toxicity and Subacute (5 Days) Toxicity.- a) Method of Study.- b) Results.- ?) Acute Toxicity.- ?) Subacute Toxicity.- 2. Long-term Toxicity (3 Months).- a) Method of Study.- b) Results.- ?) Trials on Rabbits.- ?) Trials on Dogs.- 3. Teratogenic Action.- a) Chick Embryo.- b) Mice.- c) Rabbits.- d) Conclusion.- 4. Carcinogenic Effect.- a) Material and Method.- ?) Subcutaneous Administration.- ?) Oral and Intraperitoneal Administration.- b) Results.- ?) Subcutaneous Administration.- ?) Oral and Intraperitoneal Administration.- c) Conclusion.- II - Clinical and Therapeutic Study.- 6: Posology.- 1. Dosage with Rubidomycin.- 2. Presentation of Rubidomycin.- 3. Route of Administration.- 4. Dosage.- 5. General Management of Treatment. Precautions.- a) Symptomatic Treatment.- b) Place of Treatment.- c) Special Treatment of Hyperleukocytic Forms and Very Active Multiple Drug Therapy.- 6. Symptomatic Treatment.- a) Isolation.- b) Platelet Transfusion.- c) Bacterial Infections.- ?) Antibiotic Treatment before the Stage of Aplasia.- ?) Antibiotic Treatment during the Stage of Aplasia.- ?) Minimum Inhibiting Concentration.- ?) Choice of Antibiotic. Concept of Bactericidal Power.- ?) Antibiotic Combinations.- ?) Problems of Fungal Infections.- ?) Duration of Antibiotic Treatment.- d) Leukocyte Transfusions from Donors with Chronic Myeloid Leukemia at the Myelocytic Stage.- 7: Therapeutic Episodes and Accidents.- 1. Marrow Insufficiency.- a) General Characteristics.- b) Special Characteristics.- 2. Cardiac Complications.- a) Cardiac Complications Observed during and after Lengthy Treatment.- b) Cardiac Complications Observed during Less Prolon

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