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Book by Dimmock Nigel J
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Understanding neutralization is particularly relevant to an appreciation of the interaction between a virus and its antibody-synthesizing host since it is likely that viruses and the antibody system have evolved in response to reciprocally imposed selective pressures. Neutralization of viruses which only infect non-antibody-synthesizing hosts, while of considerable interest from of points of view is de facto without any such evolutionary signifi a number cance. In this second category are viruses of plants, invertebrates, vertebrates below fish in the evolutionary scale which do not synthesize antibody and most bacteria. Viruses of organisms parasitic on or commensal with antibody synthesizing vertebrates, such as enteric bacteria, protozoa or metazoan parasites, will be in contac, with antibody at some stage of their existence, and arthropod-borne viruses which have a higher vertebrate as second host are obviously bona fide members of the first category. There is an urgent need to understand the principles by which antibodies inactivate virus infectivity since, at present, we are unable to rationally construct effective vaccines against new agents like the human immuno deficiency viruses or to improve existing vaccines. The intention of this volume is to comprehensively review neutralization and where possible to construct a unifying theory which can be tested by experimentation.
Reseña del editor
This is the first comprehensive review of the neutralization of animal viruses for several decades, intended to provide a clear exposition of current knowledge and to outline avenues for future research. The approach is mechanistic; its aim is to understand the process of neutralization and,ultimately,to demonstrate how neutralizing and/or protective antibody can be stimulated in vivo. Chapters discuss the ways in which neutralizing IgG, A and M affect the interactions of virus with its host cell, quantitative aspects of neutralization, neutralization by fragments of antibody, neutralization in vivo, and the evo- lutionarysignificance of the possession of neutralization sites. In addition, individual chapters are devoted to the neutralization of poliovirus, influenza virus and HIV.
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- VerlagSpringer
- Erscheinungsdatum2011
- ISBN 10 3642778518
- ISBN 13 9783642778513
- EinbandTapa blanda
- SpracheEnglisch
- Anzahl der Seiten164
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Understanding neutralization is particularly relevant to an appreciation of the interaction between a virus and its antibody-synthesizing host since it is likely that viruses and the antibody system have evolved in response to reciprocally imposed selective pressures. Neutralization of viruses which only infect non-antibody-synthesizing hosts, while of considerable interest from of points of view is de facto without any such evolutionary signifi a number cance. In this second category are viruses of plants, invertebrates, vertebrates below fish in the evolutionary scale which do not synthesize antibody and most bacteria. Viruses of organisms parasitic on or commensal with antibody synthesizing vertebrates, such as enteric bacteria, protozoa or metazoan parasites, will be in contac, with antibody at some stage of their existence, and arthropod-borne viruses which have a higher vertebrate as second host are obviously bona fide members of the first category. There is an urgent need to understand the principles by which antibodies inactivate virus infectivity since, at present, we are unable to rationally construct effective vaccines against new agents like the human immuno deficiency viruses or to improve existing vaccines. The intention of this volume is to comprehensively review neutralization and where possible to construct a unifying theory which can be tested by experimentation. Artikel-Nr. 9783642778513
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