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Molecular Analysis of B Lymphocyte Development and Activation (Current Topics in Microbiology and Immunology, Band 290) - Softcover

Buch 17 von 322: Current Topics in Microbiology and Immunology
 
9783642421884: Molecular Analysis of B Lymphocyte Development and Activation (Current Topics in Microbiology and Immunology, Band 290)
Softcover
ISBN 10: 3642421881 ISBN 13: 9783642421884
Verlag: Springer, 2014

Inhaltsangabe

Eugeniawaspassionatelyinterestedinunderstandingthemolecular- sisofdevelopmentandchoseashermodelsystemthedevelopmentofB andTlymphocytes. Shebeganbystudyingthetranscriptionalregulation oftheTcell-specificgene,Thy-1,asagraduatestudentinFrankGrosveld s labatMillHill,London. Thereafter,sheturnedherattentiontothetopicof V(D)Jrecombination,firstasapostdoctoralfellowwithDavidBaltimore attheWhiteheadInstituteinCambridge,Massachusettsandsubsequently inherownlaboratoryatMountSinaiSchoolofMedicineinNewYorkCity. Eugeniamadefundamentaldiscoveriesconcerningthebiochemicalme- anismofthisreaction,andhowdefectsinitscentralenzymaticcom- nents,RAG1andRAG2,canleadtoahumanseverecombinedimmuno- ficiencydisorder,knownasOmennsyndrome. Atthetimeof herdeath, shehadbeenaHowardHughesMedicalInstituteinvestigatorforlessthan ayear,buthadalreadyassembledalaboratoryof15peopleworkingonan extensivearrayoftopicsinearlylymphocytedevelopmentandV(D)J- combination. Eugenialivedeachmomentofherlifewithanintensityfittingforthe cityinwhichshelived. LikeManhattan,shesleptlittle. Sheexpectedagreat dealofherself,andonlyalittlelessfromthosewithwhomsheworked. - geniaalsohadhighexpectationsforthescientificprocessandwasouts- keninherpraiseorcondemnationofthosewhometorfellshortofthose expectations. Shewasquicktoformanopinionanddevotedherselffe- ciouslytofriendshipsandhypotheses. PerhapsthegreatesttestimonytoEugeniaistheaffectionandreverence feltforherby themembersof herlab. Whilethisstemmedinnosmall partfrompredictablesources-herkeenmindandbroadknowledge-it founditsdeepestsourceinEugenia sabilitytotransmit,byexampleand word,her love of a life of learning and exploration. SandroSantigata,a graduatestudentinEugenia slab,capturedthiseloquentlyatthememorial serviceforEugeniaandAndrew,whenhesaid: VIII Obituary "Ifyouhaveeverbeenspellboundbyagreatstatue,enrapturedbyits strengthandvitality,enthralledbyitspurity,purposeandgraceandupli- edbythesenseofhopethatitsparkswithinyoursoul,thenyouhave- readyunderstoodwhyIadoredEu

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Von der hinteren Coverseite

The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.

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Verlag
Springer
Erscheinungsdatum
2014
Sprache
Englisch
ISBN 10 
3642421881
ISBN 13 
9783642421884
Einband
Taschenbuch
Anzahl der Seiten
272
Herausgeber
Singh Harinder, Grosschedl Rudolf
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