Metallopharmaceuticals I: DNA Interactions (Topics in Biological Inorganic Chemistry, 1, Band 1) - Hardcover

 
9783540648895: Metallopharmaceuticals I: DNA Interactions (Topics in Biological Inorganic Chemistry, 1, Band 1)
Hardcover
ISBN 10: 3540648895 ISBN 13: 9783540648895
Verlag: Springer, 1999

Inhaltsangabe

Biological inorganic chemistry is a field of research at the interface of inorganic and biological chemistry. The rapidly developing insights into the role of metals in biological systems has far-reaching implications not only for biological science but also for related disciplines, ranging from molecular medicine to the environment. In each volume the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, receives a comprehensive summary and critical overview of a topic of high current interest written by leading international experts.

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Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.

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Verlag
Springer
Erscheinungsdatum
1999
Sprache
Englisch
ISBN 10 
3540648895
ISBN 13 
9783540648895
Einband
Gebundene Ausgabe
Anzahl der Seiten
211
Herausgeber
Clarke Michael J., Sadler Peter J.
Kontakt zum Hersteller
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Deutschland

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