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Stereochemical Aspects of Drug Action and Disposition: v. 153 (Handbook of Experimental Pharmacology) - Hardcover

 
9783540415930: Stereochemical Aspects of Drug Action and Disposition: v. 153 (Handbook of Experimental Pharmacology)
Hardcover
ISBN 10: 3540415939 ISBN 13: 9783540415930
Verlag: Springer, 2003

Inhaltsangabe

Preface.- Section 1. Chemical Aspects: 1. Recent Developments in Asymmetric Organic Synthesis:Principles and Examples. 2. Stereoselective separations: Recent Advances in Capillary Electrophoresis and High-Performance Liquid Chromatography. 3. Stereochemical Issues in Bioactive Natural Products. 4. Drug Racemization and Its Significance in Pharmaceutical Research. 5. Physical Properties and Crystal Structures of Chiral Drugs.- Section 2. Experimental Pharmacology.- 6. Chiral Recognition in Biochemical Pharmacology: An Overview. 7. Enantioselectivity in Drug-Receptor Interactions. 8. Mechanisms of Stereoselective Binding to Functional Proteins. 9. Stereoselective Drug-Channel Interactions. 10. Toxocilogical Aspects.- Section 3. Drug Absorption, Distribution, Metabolism, Elimination: 11. Enantioselective GI Absorption:The Role of Transporters. 12. Enentioselective Plasma and Tissue Binding. 13. Stereoselective Drug Metabolism and Drug Interactions. 14. Metabolic Chiral Inversion of 2-Arylpropionic Acids. 15. Stereoselective Renal Elimination.- Section 4. Implications for Drug Development and Therapy: 16. Regulatory Requirements for the Development of Chirally Active Drugs. 17. Improving Clinical Risk / Benefit Through Stereochemistry.-

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Reseña del editor

This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.

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Verlag
Springer
Erscheinungsdatum
2003
Sprache
Englisch
ISBN 10 
3540415939
ISBN 13 
9783540415930
Einband
Tapa dura
Anzahl der Seiten
472
Herausgeber
Somogyi Andrew, Testa Bernard, Eichelbaum Michel F.
Kontakt zum Hersteller
Springer Nature Customer Service Center GmbH
ProductSafety@springernature.com

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Heidelberg
69115
Deutschland

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9783642625756: Stereochemical Aspects of Drug Action and Disposition (Handbook of Experimental Pharmacology, Band 153)

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ISBN 10:  3642625754 ISBN 13:  9783642625756
Verlag: Springer, 2012
Softcover