Transporters as Drug Carriers: Structure, Function, Substrates: 44 (Methods & Principles in Medicinal Chemistry) - Hardcover

9783527316618: Transporters as Drug Carriers: Structure, Function, Substrates: 44 (Methods & Principles in Medicinal Chemistry)

Hardcover

ISBN 10: 3527316612 ISBN 13: 9783527316618

Verlag: Blackwell Verlag GmbH, 2009

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THIS REFERENCE HANDBOOK IS THE FIRST TO PROVIDE A COMPREHENSIVE OVERVIEW, SYSTEMATICALLY CHARACTERIZING ALL KNOWN TRANSPORTERS INVOLVED IN DRUG ELIMINATION AND RESISTANCE. COMBINING RECENT KNOWLEDGE ON ALL KNOWN CLASSES OF DRUG CARRIERS, FROM MICROBES TO MAN, IT BEGINS WITH A LOOK AT HUMAN AND MAMMALIAN TRANSPORTERS. THIS IS FOLLOWED BY MICROBIAL, FUNGAL AND PARASITIC TRANSPORTERS WITH SPECIAL ATTENTION GIVEN TO TRANSPORT ACROSS THOSE PHYSIOLOGICAL BARRIERS RELEVANT FOR DRUG UPTAKE, DISTRIBUTION AND EXCRETION. AS A RESULT, THIS KEY RESOURCE LAYS THE FOUNDATIONS FOR UNDERSTANDING AND INVESTIGATING THE MOLECULAR MECHANISMS FOR MULTIDRUG RESISTANCE IN CANCER CELLS, MICROBIAL RESISTANCE TO ANTIBIOTICS AND PHARMACOKINETICS IN GENERAL. FOR ANYONE WORKING WITH ANTIBIOTICS AND CANCER CHEMOTHERAPEUTICS, AS WELL AS BEING OF PRIME INTEREST TO BIOCHEMISTS AND BIOPHYSICISTS.

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Cr�ticas:

"Overall, the book is well organized and the topics are clearly and easily accessible. This book offers many strengths ...but overall is quite worthwhile." (ChemMedChem, January 2011) "Overall, the book is a specialised text (as reflected in the price) that provides a comprehensive review of drug transporters. It would also be a welcome addition to any well stocked university library." (PJ Online, 12 November 2010)

Rese�a del editor:

This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion. As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

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