Drug Testing in vitro: Breakthroughs and Trends in Cell Culture Technology - Hardcover

Über die Autorin bzw. den Autor

Dr. Uwe Marx
After finishing medical training Uwe Marx received his doctorate degree in immunology from the Humboldt University, Berlin. In 1995 Dr. Marx was appointed Head of the Department of Medical Biotechnology at Leipzig University and joined ProBioGen, Berlin, in 2000 as Chief Scientific Officer.
With more than 20 years of experience in protein drug development and improvement of cell culture techniques, Uwe Marx has published more than 50 scientific papers and holds numerous patents.
 
Dr. Volker Sandig
Volker Sandig studied medicine and received his PhD in molecular biology from the Humboldt University, Berlin. He designed experimental strategies for adenovirus based tumor treatment and directed research projects in cell cycle regulation and artificial promoters at the Max Planck Society and Hepavec, a former Berlin-based biotech company. He then joined Merck Research Laboratories, USA and was appointed Vice President Molecular Biology and Virology at ProBioGen, Berlin, Germany in 2000.

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Here, expert scientists from industry and academia describe an emerging platform technology with tremendous potential. Human micro-organoid in-vitro test systems could well be the next breakthrough in overcoming two major obstacles for developing new therapeutics. Firstly, they allow the identification of the biological effects of new drugs that involve systemic interactive networks specific to humans. Secondly, they facilitate the testing of human genetic diversity and genetic predisposition. In addition, there is increased industrial interest in these test systems to comply with such regulative measures as the cosmetics directive or the European REACH program for the registration, evaluation and authorization of chemicals.

This highly topical handbook is divided into four parts, the first providing an overview of emerging in-vitro culture technologies. Part II covers primary tissues and cell lines in drug screening/testing. Part III emphasizes conflicting ethical, regulatory and commercial requirements for drug testing and screening on human micro-organoids in vitro as a viable alternative to animal testing,. The final part concludes with the tremendous potential of the in-vitro drug evaluation platform technology, using human immune micro-organoids as a prime example.

The book is introduced by a short foreword by Rolf Krebs, former president of the European Federation of Pharmaceutical Industries and Associations and of the International Federation of Pharmaceutical Manufacturers Associations, as well as a Member of the Board of Directors of the Chemical Industry Association.

The result is essential reading for professionals dealing with drug development and testing, or chemical risk assessment.