Über die Autorin bzw. den Autor

Born in Strasbourg, France in 1955, Paul Knochel studied at the University of Strasbourg and gained his PhD at the ETH-Zurich under Prof. D. Seebach. He spent 4 years at the CNRS of the University Pierre and Marie Curie at Paris under Professor J.-F. Normant and a one-year post-doc at Princeton University, under Professor M. F. Semmelhack. In 1987 he accepted an assistant professorship at the University of Michigan at Ann Arbor, Michigan, becoming a full professor there in 1991. One year later he moved to Philipps-University at Marburg, Germany as Professor in Organic Chemistry. In 1999, he transferred to the Chemistry Department at Ludwig-Maximilians-University in Munich, Germany, where he remains today. Professor Knochel's research interests include the development of novel organometallic reagents and methods for use in organic synthesis, asymmetric catalysis and natural product synthesis.

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Functionalized organometallics are highly reactive and selective, opening the door to a whole new range of synthetic pathways and new methods for successful organic synthesis.<br> Edited by one of the leading experts in the field with a high reputation within the community, this handbook is the first to cover the field in its entirety, not merely focusing on one single metal but on the whole range of different compounds. Each chapter includes the scope of the reactions, as well as their limitations and many useful practical details<br> In short, the authors provide everything there is to know about this hot topic. By imparting their knowledge, they show readers how to significantly improve their synthetic strategies -- making this a must for chemists working with and on organometallics, organic chemists, catalytic chemists, and those in industry.

Aus dem Klappentext

Functionalized organometallics are highly reactive and selective, opening the door to a whole new range of synthetic pathways and new methods for successful organic synthesis.
Edited by one of the leading experts in the field with a high reputation within the community, this handbook is the first to cover the field in its entirety, not merely focusing on one single metal but on the whole range of different compounds. Each chapter includes the scope of the reactions, as well as their limitations and many useful practical details
In short, the authors provide everything there is to know about this hot topic. By imparting their knowledge, they show readers how to significantly improve their synthetic strategies -- making this a must for chemists working with and on organometallics, organic chemists, catalytic chemists, and those in industry.

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Handbook of Functionalized Organometallics

Application in Synthesis, 2 VolumesBy Paul Knochel

John Wiley & Sons

Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
All right reserved.
ISBN: 978-3-527-31131-6

Preface

Since the pioneering work of Frankland and Wurtz, organometallic intermediates have occupied a central position in organic synthesis. The chemical behavior of organometallic reagents depends greatly on the nature of the metal and on the carbon hybridization. Each metal has intrinsic chemical properties, which confer a specific reactivity for forming new carbon-carbon bonds to the organic moiety attached to it. The nature of the metal substituents (ligands) enables a modulation and adjustment to this reactivity of the organometallic to the organic substrate. Choosing the correct metal and ligand sphere to achieve any given transformation represents a major task for the synthetic chemist. During the course of the last thirty years, chemists have realized that this fine-tuning of the reactivity of organometallics has a number of synthetic advantages (selectivity, yields, reaction conditions, etc.). However, they have also noticed that a broad range of functionalities can be present in the organometallic intermediate itself and therefore these reagents allow for the preparation of polyfunctional molecules without the need for multiple protection and deprotection steps.

This book summarizes the synthetic knowledge available as of 2005 for preparing functionalized organometallics and the optimum conditions for their reacting with electrophilic species. It also covers main group and transition organometallics while outlining in detail the functional group compatibility for each class of organometallics in the various book chapters.

Organometallic chemistry is a field of chemistry that is constantly experiencing discoveries and is one of the motors of chemistry. Thus it can be expected that numerous new synthetic methods based on the use of functionalized organometallics will be added to the chemistry presented in this book within the next few years. An effort has been made to present the material in an attractive layout with many equations and numerous practical details, allowing for rapidly entry in the field. Therefore, this book is well suited for master and PhD students, for advanced undergraduate students, as well as industrial process and research chemists.

Munich, August 2005 Paul Knochel

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