Rare Kidney Tumors: Comprehensive Multidisciplinary Management and Emerging Therapies - Hardcover

Über die Autorin bzw. den Autor

Dr. Nizar M. Tannir, is Professor and Deputy Chair of the Department of Genitourinary Medical Oncology at MD Anderson Cancer Center, and is a clinical investigator with expertise in trial design. Dr. Tannir has conducted numerous clinical trials in renal cell carcinoma (RCC), and is an expert on rare kidney cancers, particularly, translocation RCC (Xp11.2) and renal medullary carcinoma (RMC). He co-chairs a think-tank on RMC, bringing together world experts from different fields to accelerate discovery and novel therapeutics for this devastating orphan cancer. Dr. Tannir has authored more than 150 original manuscripts and several book chapters. He is editor of Renal Cell Carcinoma, a book published by Oxford University Press in 2014. Dr. Tannir co-chairs a yearly urological oncology symposium at MDACC, and serves on the scientific and medical advisory board of the Kidney Cancer Association. Dr. Tannir’s research is focused on deciphering the molecular underpinnings of RMC and Xp11.2. He is Principal Investigator of several clinical trials in advanced clear-cell and non-clear cell RCC, including rare variants, with emphasis on identification of prognostic and predictive biomarkers. Dr. Tannir was voted Teacher of The Year four times, and received numerous awards including the Gerald P. Bodey Award for Excellence in Education, the Waun Ki Hong Award for Leadership in Education, and the Melvin L. Samuels Award for Excellence in Patient Care.

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This book provides clinicians with clear guidance on treatment decision-making in patients with rare kidney cancers. After a brief review on epidemiology, pathology, and biology, each chapter focuses on the multidisciplinary management of a particular tumor subtype using the full range of available cancer therapy modalities, including surgery, radiotherapy, chemotherapy, targeted therapies, and immunotherapy. Emerging therapies and future directions in the management of each cancer subtype are also discussed. The chapters are all written by multidisciplinary teams of international experts comprising at least a urologist, a medical oncologist, and a pathologist.

Rare kidney cancers represent 15% of renal cell carcinomas. In comparison with clear cell renal cell carcinomas, little is known about the biology of such cancers, and few trials have reported on the efficacy of targeted therapies in the metastatic setting. Optimal management thus poses significant challenges and oftenrequires a multidisciplinary team. This book will be an ideal reference guide for all clinicians involved in the care of patients with these orphan tumors.