The Functional Nucleus - Hardcover

 
9783319388809: The Functional Nucleus
Hardcover
ISBN 10: 3319388800 ISBN 13: 9783319388809
Verlag: Springer, 2016

Inhaltsangabe

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

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Über die Autorin bzw. den Autor

David P. Bazett-Jones
The Hospital for Sick Children, Toronto, ON, Canada 

                
Graham Dellaire
Dalhousie University, Halifax, NS, Canada

Von der hinteren Coverseite

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

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Verlag
Springer
Erscheinungsdatum
2016
Sprache
Englisch
ISBN 10 
3319388800
ISBN 13 
9783319388809
Einband
Gebundene Ausgabe
Auflage
1
Anzahl der Seiten
519
Herausgeber
Bazett-Jones David P., Dellaire Graham
Kontakt zum Hersteller
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Heidelberg
69115
Deutschland

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