Chromosomal Instability in Cancer Cells (Recent Results in Cancer Research, 200, Band 200) - Hardcover

Buch 141 von 157: Recent Results in Cancer Research
 
9783319202907: Chromosomal Instability in Cancer Cells (Recent Results in Cancer Research, 200, Band 200)
Hardcover
ISBN 10: 3319202901 ISBN 13: 9783319202907
Verlag: Springer, 2015

Inhaltsangabe

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

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Von der hinteren Coverseite

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

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Verlag
Springer
Erscheinungsdatum
2015
Sprache
Englisch
ISBN 10 
3319202901
ISBN 13 
9783319202907
Einband
Gebundene Ausgabe
Auflage
1
Anzahl der Seiten
231
Herausgeber
Ghadimi B. Michael, Ried Thomas
Kontakt zum Hersteller
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Deutschland

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ISBN 10:  3319349627 ISBN 13:  9783319349626
Verlag: Springer, 2016
Softcover