Structural and Functional Characterization of the Immunoproteasome (Springer Theses) - Hardcover

Huber, Eva Maria

 
9783319015552: Structural and Functional Characterization of the Immunoproteasome (Springer Theses)
Hardcover
ISBN 10: 3319015559 ISBN 13: 9783319015552
Verlag: Springer, 2013

Inhaltsangabe

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

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Über die Autorin bzw. den Autor

Eva Huber studied biochemistry at the Technische Universität München (TUM) from 2004 till 2009. For her master studies, which were funded by the Studienstiftung des deutschen Volkes, she received the Jürgen-Manchot Studienpreis from the faculty of chemistry of the TUM. During her postgraduate studies (2009-2013) in the group of Prof. Groll at the TUM she succeeded in the elucidation of the mouse immuno- and constitutive proteasome X-ray structures in their unliganded state and in complex with the immunoproteasome-selective compound ONX 0914. For these results she has been awarded the “Management Engineers Presidential Award” in 2012.

Von der hinteren Coverseite

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

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Verlag
Springer
Erscheinungsdatum
2013
Sprache
Englisch
ISBN 10 
3319015559
ISBN 13 
9783319015552
Einband
Gebundene Ausgabe
Anzahl der Seiten
101
Kontakt zum Hersteller
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Deutschland

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ISBN 10:  3319378104 ISBN 13:  9783319378107
Verlag: Springer, 2016
Softcover