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Book by Greinix Hildegard T Knobler Robert
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Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer and has demonstrated efficacy in T-cell mediated disorders including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, scleroderma, Crohn's disease and diabetes mellitus. Due to its exceptional safety profile ECP has gained wide international acceptance through the efforts of leading clinical investigators. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and are the basis for further clinical investigations.
Biografía del autor:
Univ. Prof. Dr. Hildegard T. Greinix, Prof. Dr. Robert Knobler, both Medical University of Vienna Departments of Internal Medicine I and Dermatology Vienna, Austria.
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- VerlagDe Gruyter
- Erscheinungsdatum2017
- ISBN 10 3110275945
- ISBN 13 9783110275940
- EinbandTapa dura
- Anzahl der Seiten228
- HerausgeberGreinix Hildegard T., Knobler Robert
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Buchbeschreibung Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Extracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient's blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders. Artikel-Nr. 9783110275940
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