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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses) - Hardcover

Buch 522 von 797: Springer Theses

Ferraz De Paiva, Raphael Enoque

 
9783030008529: Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses)
Hardcover
ISBN 10: 3030008525 ISBN 13: 9783030008529
Verlag: Springer, 2018

Inhaltsangabe

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

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This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.


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Verlag
Springer
Erscheinungsdatum
2018
Sprache
Englisch
ISBN 10 
3030008525
ISBN 13 
9783030008529
Einband
Gebundene Ausgabe
Auflage
1
Anzahl der Seiten
190
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