Recent surveys have shown that over 60% of papers published in the biomedical literature are statistically weak or inappropriate. For scientific and welfare reasons it is clearly important to understand how to increase power and reduce (or cope with) variation whilst conducting experiments. This handbook is aimed at all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when designing more complex experiments. It covers many aspects of experimental design, such as choice of experimental animal, which are not considered by most statistics textbooks. It does not cover the more advanced designs or statistical methods, so it should be used in conjunction with more conventional statistics textbooks. This handbook also contains links to a number of web sites of interest to those seeking further information related to statistical and experimental design. Table of Contents: Acknowledgement; Preface; Basic principles of the design of animal experiments; Choice of animals; Understanding and controlling variation; The design of experiments; The determination of sample size; Presenting and interpreting the results and making decisions; Concluding remarks: putting the project together; Appendix 1: Brief notes on statistical packages: Appendix 2: Further reading; References.9 This book covers especifically the interphase between laboratory animal science and experimental design. Written by British biostatistians with excellent training in animal experiments.
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