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Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique.

This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

Aus dem Klappentext

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique.

This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

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Fragment-Based Drug Discovery

The Royal Society of Chemistry

Contents

Personal Essay: Fragments in the Blogosphere Daniel A. Erlanson, 
Personal Essay: Adventures and Experiences in Fragment-Based Drug Discovery Martin J. Drysdale, 
Chapter 1 Different Flavours of Fragments Chris Abell and Claudio Dagostin, 
Chapter 2 Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support Anthony M. Giannetti, Houston N. Gilbert, Donald P. Huddler, Mac Reiter, Chris Strande, Keith E. Pitts, and Brandon J. Bravo, 
Chapter 3 Applications of NMR in Fragment-Based Drug Design Isabelle Krimm, 
Chapter 4 Current Status and Future Direction of Fragment-Based Drug Discovery: A Computational Chemistry Perspective Ian D. Wall, Michael M. Hann, Andrew R. Leach, and Stephen D. Pickett, 
Chapter 5 Fragment Screening of G Protein-Coupled Receptors Miles Congreve and Robert Cooke, 
Chapter 6 Fragment-Based Lead Discovery Applied to Protein–Protein Interactions Roderick E. Hubbard, 
Chapter 7 Fragment-Based Discovery of Allosteric Ligands Steven Howard, 
Chapter 8 Fragment-Based Discovery of Antibacterials Christina Spry and Anthony G. Coyne, 
Chapter 9 Exploring Fragment Screening and Optimization Strategies Using Acetylcholine-Binding Protein Ewald Edink, Gerdien E. de Kloe, and Iwan J. P. de Esch, 
Chapter 10 Fragment-Based Approaches to Epigenetic Targets Chun-wa Chung and Paul Bamborough, 
Subject Index,