In biotechnology and bioengineering, small molecules can be used to increase the efficiency reduce the cost and damage to the environment of certain bioprocesses. This book introduces readers to the important field of chemically promoted biotechnology and bioengineering and presents the theory behind the biotechnology of enzymatic reactions and how they can be chemically enhanced. The book covers chemical modulators for enzymatic reactions, chemically promoted biotechnology in plant cell cultures, chemically promoted biotechnology for plant protection and future prospects for the field. Knowledge gained allows both chemists to make use of biotechnology to solve chemical problems in an environmentally-friendly way, and biologists to make use of chemistry to increase biotechnological efficiency. This book is useful for scientists in a broad range of disciplines, including agricultural chemistry, pesticide science, medicinal chemistry, biochemistry, bio-organic chemistry, cell and molecular biology. Students and researchers in both academia and industry will find it a useful handbook.
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Xuhong Qian is Professor of bioorganic chemistry and engineering, and also President of East China University of Science and Technology. He has published more than 250 SCI and EI papers in chemistry, chemical biology, chemically promoted biotechnology/bioengineering with the other's SCI citations more than 3600 (H-index 30). He was also President (2007-2008) of Asian Pacific Confederation of Chemical Engineering (APCChE), now is a member of Advisory Commission for Chemistry, National Natural Science Foundation of China (2008-), Fellow of The Royal Society of Chemistry, UK (2009-), Ambassador Scientist of Alexander von Humboldt Foundation, Germany (2008-), also member, Chinese Academy of Engineering (12/2011-).
Zhenjiang Zhao is an Associate Professor of East China University of Science and Technology from 2010. He received Ph.D in Applied Chemistry from East China University of Science and Technology in 2004. From 1990 to 2001, 2004 to 2010, he worked in China Lucky Film Company and a Pharma. Inc. His research interests focus on Medicinal Chemistry, mainly on enzyme inhibitors and argochemicals. He has published 15 SCI papers and some patents.
Yufang Xu is a Professor of East China University of Science and Technology. She received her Ph.D. degree in Chemistry from East China University of Science and Technology in 1994. From 1999 to 2001 she worked as postdoctoral fellow in Tokyo Medical and Dental University, Japan. Her research interests focus on small organic molecules to regulate the bioprocess, includes chemically promoted biotechnology/bioengineering and the design and synthesis of fluorescent probes to response the hypoxia and related enzymes for diagnosis and treatment of related diseases. She has published more than 90 papers in J Am. Chem. Soc., Ang. Chem. int., J. Med. Chem., Chem. Commun, Biotech
Jianhe Xu is the Professor and Director of State Key Laboratory of Bioreactor Engineering at East China University of Science and Technology. He is the Cheungkong Professor of Chinese Ministry of Education. He graduated from Tsinghua University in 1987, finished his Ph. D from East China University of Science and Technology and Kyoto University in 1995. He is Editors for Applied Biochemistry and Biotechnology, Biotechnology and Bioprocess Engineering. He has published more than 150 SCI papers in chemical biology, chemically promoted biotechnology/bioengineering with the other's SCI citations of more than 1000 times.
In biotechnology and bioengineering, small molecules can be used to increase the efficiency reduce the cost and damage to the environment of certain bioprocesses. This book introduces readers to the important field of chemically promoted biotechnology and bioengineering and presents the theory behind the biotechnology of enzymatic reactions and how they can be chemically enhanced.
The book covers chemical modulators for enzymatic reactions, chemically promoted biotechnology in plant cell cultures, chemically promoted biotechnology for plant protection and future prospects for the field. Knowledge gained allows both chemists to make use of biotechnology to solve chemical problems in an environmentally-friendly way, and biologists to make use of chemistry to increase biotechnological efficiency.
This book is useful for scientists in a broad range of disciplines, including agricultural chemistry, pesticide science, medicinal chemistry, biochemistry, bio-organic chemistry, cell and molecular biology. Students and researchers in both academia and industry will find it a useful handbook.
In biotechnology and bioengineering, small molecules can be used to increase the efficiency reduce the cost and damage to the environment of certain bioprocesses. This book introduces readers to the important field of chemically promoted biotechnology and bioengineering and presents the theory behind the biotechnology of enzymatic reactions and how they can be chemically enhanced.
The book covers chemical modulators for enzymatic reactions, chemically promoted biotechnology in plant cell cultures, chemically promoted biotechnology for plant protection and future prospects for the field. Knowledge gained allows both chemists to make use of biotechnology to solve chemical problems in an environmentally-friendly way, and biologists to make use of chemistry to increase biotechnological efficiency.
This book is useful for scientists in a broad range of disciplines, including agricultural chemistry, pesticide science, medicinal chemistry, biochemistry, bio-organic chemistry, cell and molecular biology. Students and researchers in both academia and industry will find it a useful handbook.
Chapter 1 From Chemical Biology to Its Technology and Engineering Xuhong Qian, Zhenjiang Zhao, Jian-He Xu, Yufang Xu, Yi-Heng Percival Zhang, Fengxian Hu, Jingyan Zhang, and Yang-Chun Yong,
Chapter 2 Chemical Modulators for Enzymatic Reactions,
Chapter 3 Regulation of Non-canonical DNA Structures by Small Molecules and Carbon Materials Chong Wang, Jingyan Zhang, and Shouwu Guo,
Chapter 4 Chemical Biotechnology of In Vitro Synthetic Biosystems for Biomanufacturing Zhiguang Zhu and Yi-Heng Percival Zhang,
Chapter 5 Chemical Bioengineering in Microbial Electrochemical Systems Dan-Dan Zhai and Yang-Chun Yong,
Chapter 6 Chemical Bioengineering in Plant Cell Culture Fengxian Hu, Yufang Xu, and Zhenjiang Zhao,
Chapter 7 Chemical Biotechnology for Plant Protection Zhenjiang Zhao, Yufang Xu, and Xuhong Qian,
Subject Index,
From Chemical Biology to Its Technology and Engineering
XUHONG QIAN, ZHENJIANG ZHAO, JIAN-HE XU, YUFANG XU, YI-HENG PERCIVAL ZHANG, FENGXIAN HU, JINGYAN ZHANG, AND YANG-CHUN YONG
Shanghai Key Laboratory of Chemical Biology and State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Cell Free Bioinnovations Inc., 2200 Kraft Drive, Suite 1200B, Blacksburg, VA 24060, USA; School of Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China; Biofuels Institute, School of the Environment, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China
E-mail: xhqian@ecust.edu.cn
1.1 The History and Applications of Biotechnology
The term 'biotechnology' first appeared in Manchester University, England, early in the 20th century. In 1912, C. Weizmann isolated a strain of Clostridium acetobutylicum that converted carbohydrate into butanol, acetone, and ethanol. In 1923, T. Walker commenced undergraduate education in the department of fermentation industries; the name of this department was then changed to industrial biochemistry, similar to 'biotechnology'. K. Ereky, a Hungarian engineer and the founding father of biotechnology, first coined the word "biotechnology" in a book published in Berlin in 1919 called Biotechnologie der Fleisch-, Fett- und Milcherzeugung im landwirtschaftlichen Grossbetriebe (Biotechnology of Meat, Fat and Milk Production in an Agricultural Large-Scale Farm), in which he explained a bioprocess technology that converts raw materials into a more valuable product. He further developed this concept for the 20th century: Biotechnology means solutions to many social and natural crises, such as food and energy shortages.
In fact, biotechnology as a methodology has existed for a long time, although the term "biotechnology" did not exist then. Around 8000 BC yeast was used to make wheat wine by the Chinese, and also around 6000 BC by the Sumerians and Babylonian
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