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Supramolecular Systems in Biomedical Fields: Rsc (Monographs in Supramolecular Chemistry, 13, Band 13) - Hardcover

 
9781849736589: Supramolecular Systems in Biomedical Fields: Rsc (Monographs in Supramolecular Chemistry, 13, Band 13)
Hardcover
ISBN 10: 1849736588 ISBN 13: 9781849736589
Verlag: Royal Society of Chemistry, 2013

Inhaltsangabe

Non-covalent interactions, which are the heart of supramolecular chemistry are also the basis of most important functions of living systems. The ability to apply supramolecular chemistry principles to the life sciences, such as designing synthetic host compounds to selectively interact within biological targets, has gained wide appeal due the vast number of potential applications.

Supramolecular Systems for Biomedical Fields provides in sixteen chapters a comprehensive overview of these applications. Each chapter covers a specific topic and is written by internationally renowned experts in that area. Sensing of bioactive inorganic ions and organic substrates is the focus of several contributions, as well as interactions with proteins and nucleic acids. Specific chapters are devoted to cyclodextrins, calixarenes and cucurbiturils as most frequently used receptors, including applications such as drug delivery and protection, gene transfer and others. Other chapters address the use of combinatorial libraries, molecular imprinting techniques, enzyme assays, supramolecular gels, bioimaging, drug activation, photodynamic therapy, and antitumour metal complexes.

This timely publication will appeal to graduate students and researchers from chemical, pharmaceutical, biological, and medicinal fields interested in the supramolecular chemistry of biological systems and their practical potentials.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

Über die Autorin bzw. den Autor

Hans-Jorg Schneider has made many contributions in the field of supramolecular chemistry, in particular on mechanisms of molecular recognition including chemomechanical polymers, on cyclophane and cyclodextrin chemistry, and on synthetic enzyme and receptor analogs. The topics included synthetic allosteric complexes, polyamines, complexes with nucleotides and nucleic acids, with peptides, as well as artificial esterases and nucleases. Hans-Jorg Schneider has published over 260 papers, authored, co-authored or edited several books, including a textbook on supramolecular chemistry.

Von der hinteren Coverseite

Non-covalent interactions, which are the heart of supramolecular chemistry are also the basis of most important functions of living systems. The ability to apply supramolecular chemistry principles to the life sciences, such as designing synthetic host compounds to selectively interact within biological targets, has gained wide appeal due the vast number of potential applications.

Supramolecular Systems for Biomedical Fields provides, in sixteen chapters, a comprehensive overview of these applications. Each chapter covers a specific topic and is written by internationally renowned experts in that area. Sensing of bioactive inorganic ions and organic substrates is the focus of several contributions, as well as interactions with proteins and nucleic acids. Specific chapters are devoted to cyclodextrins, calixarenes and cucurbiturils as most frequently used receptors, including applications such as drug delivery and protection, gene transfer and others. Other chapters address the use of combinatorial libraries, molecular imprinting techniques, enzyme assays, supramolecular gels, bioimaging, drug activation, photodynamic therapy, and antitumour metal complexes.

This timely publication will appeal to graduate students and researchers from chemical, pharmaceutical, biological, and medicinal fields interested in the supramolecular chemistry of biological systems and their practical potentials.

Aus dem Klappentext

Non-covalent interactions, which are the heart of supramolecular chemistry are also the basis of most important functions of living systems. The ability to apply supramolecular chemistry principles to the life sciences, such as designing synthetic host compounds to selectively interact within biological targets, has gained wide appeal due the vast number of potential applications.

Supramolecular Systems for Biomedical Fields provides, in sixteen chapters, a comprehensive overview of these applications. Each chapter covers a specific topic and is written by internationally renowned experts in that area. Sensing of bioactive inorganic ions and organic substrates is the focus of several contributions, as well as interactions with proteins and nucleic acids. Specific chapters are devoted to cyclodextrins, calixarenes and cucurbiturils as most frequently used receptors, including applications such as drug delivery and protection, gene transfer and others. Other chapters address the use of combinatorial libraries, molecular imprinting techniques, enzyme assays, supramolecular gels, bioimaging, drug activation, photodynamic therapy, and antitumour metal complexes.

This timely publication will appeal to graduate students and researchers from chemical, pharmaceutical, biological, and medicinal fields interested in the supramolecular chemistry of biological systems and their practical potentials.

Auszug. © Genehmigter Nachdruck. Alle Rechte vorbehalten.

Supramolecular Systems in Biomedical Fields

By Hans-Jörg Schneider

The Royal Society of Chemistry

Copyright © 2013 The Royal Society of Chemistry
All rights reserved.
ISBN: 978-1-84973-658-9

Contents

Chapter 1 Introduction Hans-Jörg Schneider, 1, 
Chapter 2 Signalling Techniques in Supramolecular Systems Jealemy Galindo Millán and Leonard J. Prins, 7, 
Chapter 3 Metal Ion Sensing for Biomedical Uses David C. Magri and Carl J. Mallia, 38, 
Chapter 4 Complexation of Biomedically Important Organic Compounds Hans-Jörg Schneider, 68, 
Chapter 5 Cyclodextrins for Pharmaceutical and Biomedical Applications C. Ortiz Mellet, J. M. García Fernández and J. M. Benito, 94, 
Chapter 6 Interactions of Calix[n]arenes and Other Organic Supramolecular Systems with Proteins Florent Perret and Anthony W. Coleman, 140, 
Chapter 7 Cucurbiturils in Drug Delivery And For Biomedical Applications Na'il Saleh, Indrajit Ghosh and Werner M. Nau, 164, 
Chapter 8 Nucleic Acids as Supramolecular Targets Enrique García-España, Ivo Piantanida and Hans-Jörg Schneider, 213, 
Chapter 9 Biomolecular Interactions of Platinum Complexes Benjamin W. Harper, Feng Li, Rhys Beard, K. Benjamin Garbutcheon-Singh, Neville S. Ng and Janice R. Aldrich-Wright, 260, 
Chapter 10 Supramolecular Metal Complexes for Imaging and Radiotherapy Jürgen Schatz and Daniel Schühle, 300, 
Chapter 11 Supramolecular Gels for Pharmaceutical and Biomedical Applications Juan F. Miravet and Beatriu Escuder, 331, 
Chapter 12 Supramolecular Enzyme Assays Andreas Hennig, 355, 
Chapter 13 Constitutional Dynamic Chemistry for Bioactive Compounds Yan Zhang, Lei Hu and Olof Ramström, 397, 
Chapter 14 Molecular Imprinted Polymers for Biomedical Applications Adnan Mujahid and Franz L. Dickert, 419, 
Chapter 15 Supramolecular Approach for Tumor Imaging and Photodynamic Therapy Anurag Gupta and Ravindra K. Pandey, 451, 
Chapter 16 Designing Polymeric Binders for Pharmaceutical Applications Nicolas Bertrand, Patrick Colin, Maxime Ranger and Jeanne Leblond, 483, 
Subject Index, 518,


CHAPTER 1

Introduction


HANS-JÖRG SCHNEIDER

Universität des Saarlandes, FR Org. Chemie, D 66041 Saarbrücken

Email: ch12hs@rz.uni-sb.de


Non-covalent interactions dominate central parts of living systems, and provide a major role for chemistry in both healthcare and biotechnology. Modern synthetic methods have made it possible to prepare host compounds for virtually every target molecule, including those which function in the natural medium, water. In Chapter 13 Ramström et al. discuss how dynamic combinatorial chemistry can lead to an unlimited number of optimal ligands, inhibitors and potential drugs for biological targets. The action and development of drugs is the realm of medicinal chemistry, for which a large number of monographs and reviews is available. Nevertheless, the understanding of many biological functions, and particularly the rational design of new drugs or bioorganic self-assemblies, can take advantage of insights from the study of synthetic host–guest complexes. Thus, cation–π3 or anion–π4 interactions and their role in living systems first became apparent in artificial complexes; the same holds for many other interactions with aromatic moieties. Weak hydrogen bonds such as with C–H bonds or with organic halogens first became accessible to detailed elucidation with synthetic complexes; this applies also to, for instance, the interaction between halogen atoms and Lewis bases, and to dispersive forces. A remarkable limitation of Emil Fischer's lock-and-key principle was observed first with synthetic complexes, in which usually only 50% of the available space in a binding cavity is used; this rule was shown later to apply also to enzyme complexes.

Perhaps the most important aspect of using synthetic complexes is the possibility not only to elucidate the mechanism of all contributions to molecular recognition, but also to clarify geometric constraints — in particular to assign discrete energy values to them. This can help to develop energy scoring functions for drug design. It would have been tempting to devote some chapters to these mechanistic contributions for the understanding of non-covalent binding with biological systems. Instead the reader is pointed to the above-mentioned leading references; the present monograph tries to summarize practical applications of host–guest complexes in life sciences by means of chapters written by well-known specialists in applications, which can be grouped as follows.


1.1 Sensing/Diagnostics/Imaging

From the beginning of supramolecular chemistry, analytical applications have played a major role. Supramolecular complexes can eventually lead to direct sensing of targets in the biological matrix without sample pretreatment, which often is still necessary in order to extract, isolate and concentrate the analytes of interest. In Chapter 2 Prins et al. illustrate how very high sensitivity can be achieved with amplification pathways combining catalysis and multivalency. Based on the use of synthetic catalysts containing recognition sequences one can, for example, detect DNA targets with a sensitivity down to 5 nM; with cationic polythiophenes forming triple helices with DNA targets, an affinity corresponding to 3x10-21 M detection limit can be reached. The use of host molecules which in sensors exhibit sensitive signals upon recognition of biomedically important analytes is discussed in Chapter 3 by Magri and Mallia with respect to metal ions, and in Chapter 4 by Schneider for organic and biological compounds. Magri describes the implementation of several interaction sites within hosts functioning also as logical gates; this leads to 'lab-on-a-molecule' devices. Confocal microscopy with fluorescent ligands allows, for example, imaging of Cd2+ ions in living cells. Sensing of organic analytes comprises — from metabolites, through alkaloids to drugs and toxins — a large variety of structures as illustrated with the typical examples presented in Chapter 4. For a highly sensitive and selective detection a myriad of synthetic host compounds has been designed, which bear suitable units for mostly optical signalling. In Chapter 14 Dickert and Mujahid show that molecular imprinting (MIP) techniques not only allow economical separations, but in particular highly selective recognition, which now extends also to antibodies, cells, viruses (including HIV) and even bacteria. They demonstrate that MIP receptors possess the potential to substitute natural antibodies, and allow detection of, for example, drug metabolites from complex matrices including blood and urine. Several chapters are centred not on particular targets or methods, but on host molecules which are used most often in biomedical applications, such as cyclodextrins (CDs; Chapter 5 by Ortiz Mellet et al.), calixarenes (Chapter 6 by Coleman and Perret), and cucurbiturils (CBs; Chapter 7 by Saleh et al.). Others host molecules such as crown ethers, cyclophanes, molecular tweezers, and porphyrins also play an increasingly important role in biomedical fields; they are mentioned in several chapters, in particular Chapter 4. Cyclodextrin-based assemblies can serve for the detection of pathogens or allergens, and are more cost-effective than the immunosorbent ELISA assay. CD–mannopyranosyl conjugates on a Ru(II) fluorescent core allowed...

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Verlag
Royal Society of Chemistry
Erscheinungsdatum
2013
Sprache
Englisch
ISBN 10 
1849736588
ISBN 13 
9781849736589
Einband
Gebundene Ausgabe
Anzahl der Seiten
531
Herausgeber
Schneider Hans-Jorg
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Nicht verfügbar