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Guanosine and its derivatives have a high potential for self-recognition and self-assembly, as well as the recognition ability for other biologically important molecules. This book explores in detail these properties with the goal of increasing knowledge of the basic principles of guanosine-assembly, synthesis of new optimised materials and exploration of their electronic and optical properties. Following the work of COST Action MP0802, the aim is to design novel reproducible and well ordered supramolecular structures to serve as molecular-scale architectures for new hybrid molecular electronics. Coverage includes synthesis, characterisation and optimisation, theoretical modelling and prediction, biochemical and biorecognition properties and applications in nanotechnology especially in molecular electronics. Appealing to researchers working in the field ranging from chemists, biologists and material scientists, this title will be a welcome addition to the inter-disciplinary literature providing direction for future research and ideas for industrial applications.

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Guanine Quartets

Structure and Application

The Royal Society of Chemistry

Contents

Chapter 1, 
Introduction: From G-Quartet to G-Quadruplex and its Nanoarchitectures Lea Spindler, 1, 
Guanylic acid Self-Assembly: 100 years on Gang Wu, 3, 
Functional Assemblies made from Supramolecular G-Quadruplexes J.M Rivera, 15, 
Self-Assembly of Lipophilic Guanosines: Switching between different Assemblies Stefano Masiero, Silvia Pieraccini and, 28, 
Nanopatterning the Surface with ordered Supramolecular Architectures: Controlling the Self-Assembly of Guanine-based Hydrogen-Bonded Motifs Artur Ciesielski, Mathieu Surin, Gian Piero Spada and Paolo Samor, 40, 
Morphological Heterogeneity of Supramolecular G-DNA Polymers derived from Guanine Rich Oligonucleotides T.C. Marsh, Z.M. Henseler and M.A. Klimstra, 48, 
Thermondynamics of G-Quadruplexes C Giancola, 63, 
G-Quadruplex Nanostructures Probed at the Single Molecular Level by Force-Based Methods Soma Dhakal, Hanbin Mao, Arivazhagan Rajendran, Masayuki Endo, and Hiroshi Sugiyama, 73, 
Chapter 2, 
Introduction: Synthesis and Characterization Gian Piero Spada, 87, 
Synthesis and Properties of Oligonucleotides Forming G-Quadruplexes A. Aviño, andR. Eritja, 89, 
Electrochemical Characterization of Guanine Quadruplexes A. — M. Chiorcea — Paquim, P. Santos, V.C. Diculescu, R. Eritja and A.M. Oliveira-Brett, 100, 
AFM of Guanine Rich Oligonucleotide Surface Structures James Vesenka, 110, 
Solution Dynamics and Structure of G-Quadruplexes Studied by Dynamic Light Scattering Lea Spindler, 121, 
GMP-Quadruplex Structures in Dilute Solutions and in Condensed Phases: An X-Ray Scattering Analysis E. Jr. Baldassarri, M. G. Ortore, A. Gonnelli, M. Marcinekova, S. Mazzoni, M. L. Travaglini and P. Mariani, 135, 
Temperature-Gradient Gel Electrophoresis: Unfolding of G-Quadruplexes Viktor Viglaský, Katarina Tlucková, Petra Tóthová and L'ubos Bauer, 147, 
Specific Behaviour of Guanosine in Liponucleoside Thin Films L. Coga, M. Devetak, S. Masiero, G.P. Spada and I. Drevensek-Olenik, 154, 
Chapter 3, 
Theoretical Modelling, Analysis and Prediction Shozeb Haider, 165, 
Fundamentals and Applications of the Geometric Formalism of Quadruplex Folding Mateus Webba da Silva and Andreas Ioannis Karsisiotis, 167, 
Guanine, Xanthine and Uric Acid Assemblies: Comparative Theoretical and Experimental Studies Gábor Paragi, János Szolomájer, Zoltán Kupihár, Gyula Batta, Zoltán Kele, Petra Pádár, Botond Penke, Hester Zijlstra, Celia Fonseca Guerra, F. Matthias Bickelhaup, and Lajos Kovács, 179, 
Computational Methods for Studying G-Quadruplex Nuceic Acids B. Islam, V. D'Atri, M. Sgobba, J. Husby and S. Haider, 194, 
Chapter 4, 
Introduction: Recognition of Quadruplexes Mateus Webba da Silva, 213, 
Biological Functions of G-Quadruplexes Nancy Maizels, 215, 
Regulation of Gene Transcription by DNA G-Quadruplexes Michael Fry, 223, 
The Reality of Quadruplex Nucleic Acids as a Therapeutic Target G. N. Parkinson, 237, 
Screening for Quadruplex Binding Ligands: A Game of Chance? E. Largy and M.-P. Teulade-Fichou, 248, 
Recognition of G-Quadruplexes by Metal Complexes Kogularamanan Suntharalingam and Ramon Vilar, 263, 
Chapter 5, 
Introduction: Applications in Bioanalytics, Therapy and Molecular Electronics Wolfgang Fritzsche, 275, 
Catalytic G-Quadruplexes Dipankar Sen, 277, 
Catalytic G-Quadruplexes for the Detection of Telomerase Activity Joanna Kosman, Bernard Juskowiak, 285, 
G-Quadruplex forming Oligonucleotides with Tailor-made Modifications as effective aptamers for Potential Therapeutic Applications Domenica Musumeci and Daniela Montesarchio, 292, 
Dep-Based Integration of G-Quadruplex Structures Christian Leiterer, Andreas Kopielski, Irit Lubitz, Alexander Kotlyar, Antti-Pekka Eskelinen, Päivi Törmä and Wolfgang Fritzsche, 306, 
Conductive Behaviour of G4-DNA-Silver Nanoparticle Structures T. Parviainen, G. Eidelshten, A. Kotlyar, and J. J. Toppari, 314, 
Novel Materials for Molecular Electronics – Synthese and Characterization of Long G4-DNA Dvir Rotem, Gennady Eidelshtein, Alexander Kotlyar and Danny Porath, 324, 
Subject Index, 337,