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Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach - Hardcover

 
9781846285158: Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach
Hardcover
ISBN 10: 1846285151 ISBN 13: 9781846285158
Verlag: Springer, 2008

Inhaltsangabe

Although osteoporosis has been de? ned as “a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk,” it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized “osteoporosis of old age” and distinguished it from osteoporosis associated with the postme- pausal state, as well as from osteoporosis from disuse, osteoporosis from malnutrition, and other forms of osteoporosis. He nevertheless pointed out that it was unclear how much of osteoporosis is due to old age per se, in view of the fact that “in many cases osteoporosis of disuse, of malnutrition, of the postmenopausal state and of senility are inseparably superimposed. ” In this volume, Duque and Kiel have gathered an international panel of experts to highlight the unique features of senile osteoporosis and cons- eration of this disease spans the very basic through the clinical and the epidemiologic. As an organ which harbors stem cells, bone may clearly in? uence not only its own regeneration but also the regeneration of other tissues, notably the hematopoietic system.

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Osteoporosis in Older Persons - Pathophysiology and Therapeutic Approach has the most up-to-date information about the pathophysiology and new therapeutic alternatives.

Until recently most effort concerning osteoporosis research was directed mainly at the mechanisms of a type of osteoporosis known as post-menopausal osteoporosis. It was only just recently that a new syndrome, osteoporosis in older persons, was recognized as a new entity with its own pathophysiology and potential treatments.
 
Highlights of this book include:-
 
- Many illustrations showing the basic biological pathways involved in bone aging, as well as the potential links between aging and the changes in bone biology
- Figures showing the potential therapeutic targets in bone to prevent and treat osteoporosis, complemented by a complete review on the current treatments
- Descriptions of the epidemiology of osteoporotic fractures and their impact on health care costs
- Coverage of fractures and their relationship with falls, including new invasive and non-invasive therapeutic approach for osteoporotic fractures
- A complete review of future treatments is included explaining their biological basis as well as their potential indications
 
Written by leading clinicians and practitioners in the field this book will be of use to those involved with aging bone research, geriatricians, gerontologists, and bone biologists, as well as offering medical trainees an understanding of the mechanisms of osteoporosis in the older person, with a practical approach to diagnosis and treatment in mind.

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Verlag
Springer
Erscheinungsdatum
2008
Sprache
Englisch
ISBN 10 
1846285151
ISBN 13 
9781846285158
Einband
Gebundene Ausgabe
Anzahl der Seiten
204
Herausgeber
Duque Gustavo, Kiel Douglas P.
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