RNA interference (RNAi) has the potential to make major contributions towards sustainable crop production and protection with minimal environmental impacts compared to other technologies. RNAi is being developed and exploited both within plants (i.e. host-induced gene silencing, HIGS) and/or as topical applications (e.g. spray-induced gene silencing, SIGS) for targeting pest and pathogen genes and for manipulating endogenous gene expression in plants. Chapters by international experts review current knowledge on RNAi, methods for developing RNAi systems in GM plants and applications for crop improvement, crop production and crop protection. Chapters examine both endogenous systems in GM plants and exogenous systems where interfering RNAs are applied to target plants, pests and pathogens. The biosafety of these different systems is examined and methods for risk assessment for food, feed and environmental safety are discussed. Finally aspects of the regulation of technologies exploiting RNAi and the socio-economic impacts of RNAi technologies are discussed.
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Full Professor since 2006 and Director of Department 2009-2015, now chair of the PhD school in Agriculture, Food and Environmental sciences and of the UNIDO Second Level Master's Degree on Biosafety of Plant Biotechnology Cordinator of 2 COST actions (COST836, COST863) and the FP7 project KBBE, EUBerry (www.euberry.univpm.it/), as well as having participated as a partner in 5 other EU projects. He is currently coordinator of a new COST action - iPLanta (http: //www.cost-fa1405.eu/activities/short-term-scientific-missions) and partner of a new Horizon 2020 Goodberry project (http: // www. goodberry-eu.eu/). He has been coordinator and partner of several MIUR (PRIN) and Mipaf projects, as well as several projects with private companies operating in the nursery and fruit production sector. Prof. Mezzetti is author of a total of 156 publications in SCOPUS journals (IF:32) and several book chapters, topic review manuscripts and extension non-indexed publications. He has Chaired 4 ISHS international symposiums.
Jeremy Sweet is with the National Institute of Agricultural Botany (NIAB), Cambridge, UK.
Lorenzo Burgos is with CEBAS-CSIC, Spain.
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