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Bioactive Glasses: Fundamentals, Technology and Applications (Smart Materials, 23, Band 23) - Hardcover

 
9781782629764: Bioactive Glasses: Fundamentals, Technology and Applications (Smart Materials, 23, Band 23)

Inhaltsangabe

The global ageing society has significantly increased the need for implant materials, which not only replace damaged or lost tissue but are able to regenerate it. Bioactive glasses have been shown over several decades to bond with hard and soft tissue, release therapeutically active ions, and be capable of enhancing bone formation and regeneration. This book aims to give the material's scientist an up-to-date reference and guide for education, studies and research.

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Über die Autorin bzw. den Autor

Lehigh University, USA Institut de Bioenginyeria de Catalunya Federal University of São Carlos, Brazil Missouri University of Science and Technology, USA University of Minho, Portugal DISAT, Italy McGill University, Canada University of Nottingham, UK University of Manchester, UK Töölö Hospital, Finland Uni. of Erlangen-Nuremberg, Germany Universidad Complutense, Spain University of Turku, Finland Politecnico di Torino, Italy University College London, UK

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The global ageing society has significantly increased the need for implant materials, which not only replace damaged or lost tissue but are also able to regenerate it. The field of bioactive glasses has been expanding continuously over recent years as they have been shown to bond with hard and soft tissue, release therapeutically active ions, and be capable of enhancing bone formation and regeneration. In addition, they are successfully being used to re-mineralise teeth, thereby making bioactive glasses highly attractive materials in both dentistry and medicine.

Understanding the multidisciplinary requirements set by the human body s environment and the special characteristics of the different families of bioactive glasses is a key in developing new compositions to novel clinical applications. Bioactive Glasses aims to bridge the different scientific communities associated with the field of bioactive glasses with focus on the materials science point of view.  Emerging applications covered include soft tissue regeneration, wound healing, vascularisation, cancer treatment and drug delivery devices.

This book provides a comprehensive overview of the latest applications of bioactive glasses for material scientists.

Aus dem Klappentext

The global ageing society has significantly increased the need for implant materials, which not only replace damaged or lost tissue but are also able to regenerate it. The field of bioactive glasses has been expanding continuously over recent years as they have been shown to bond with hard and soft tissue, release therapeutically active ions, and be capable of enhancing bone formation and regeneration. In addition, they are successfully being used to re-mineralise teeth, thereby making bioactive glasses highly attractive materials in both dentistry and medicine.

Understanding the multidisciplinary requirements set by the human body s environment and the special characteristics of the different families of bioactive glasses is a key in developing new compositions to novel clinical applications. Bioactive Glasses aims to bridge the different scientific communities associated with the field of bioactive glasses with focus on the materials science point of view.  Emerging applications covered include soft tissue regeneration, wound healing, vascularisation, cancer treatment and drug delivery devices.

This book provides a comprehensive overview of the latest applications of bioactive glasses for material scientists.

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Bioactive Glasses

Fundamentals, Technology and Applications

By Aldo R. Boccaccini, Delia S. Brauer, Leena Hupa

The Royal Society of Chemistry

Copyright © 2017 The Royal Society of Chemistry
All rights reserved.
ISBN: 978-1-78262-976-4

Contents

Chapter 1 Melt-derived Bioactive Silicate Glasses Susanne Fagerlund and Leena Hupa, 1,
Chapter 2 Bioactive Glass-ceramics: Processing, Properties and Applications Maziar Montazerian and Edgar Dutra Zanotto, 27,
Chapter 3 Introduction to the Structure of Silicate, Phosphate and Borate Glasses Delia S. Brauer and Doris Moncke, 61,
Chapter 4 Molecular Dynamics Simulations of Bioactive Glass Structure and In vitro Reactivity Antonio Tilocca, 89,
Chapter 5 Sol-Gel Glass and Nano-Macro Porous Bioscaffolds Matthias M. Falk, Tia J. Kowal, Rui M. Almeida, Manal Saad, Mona K. Marei, Ukrit Thamma and Himanshu Jain, 105,
Chapter 6 Tailoring of Bioactive Glasses Leena Hupa and Kaj H. Karlsson, 136,
Chapter 7 Bioactive Glass Products Produced via Sintering Mohamed N. Rahaman, Wenhai Huang and B. Sonny Bal, 161,
Chapter 8 Bioactive Nanoparticles, Nanofibers, and Polymeric Nanocomposites Alvaro J. Lette and Joao F. Mano, 183,
Chapter 9 Surface Functionalization of Bioactive Glasses: Reactive Groups, Biomolecules and Drugs on Bioactive Surfaces for Smart and Functional Biomaterials Sara Ferraris and Enrica Vernè, 221,
Chapter 10 Bioactive Glass Particulate-incorporated Polymer Composites Shiva Naseri, Aldo R. Boccaccini and Showan N. Nazhat, 236,
Chapter 11 Phosphate Glass Fibres and Their Composites Kazi M. Zakir Hossain, Reda M. Felfel, David M. Grant and Ifty Ahmed, 257,
Chapter 12 Organic–Inorganic Hybrid Biomaterials Gowsihan Poologasundarampillai and Anthony L. B. Maçon, 286,
Chapter 13 Cell Interactions with Calcium Phosphate Glasses Oscar Castaño, Soledad Perez, Miguel A. Mateos-Timoneda and Elisabeth Engel, 303,
Chapter 14 Bioactive Glasses in Infection Treatment Nina Lindfors, Carlo Romano, Sara Scarponi, Drago Lorenzo, Bortolin Monica, Janek Frantzen, Pieter D. de Veij Mestdagh, David R. Colnot, Pepijn A. Borggreven and Jasper J. Quak, 316,
Chapter 15 Bioactive Glasses for Soft Tissue Engineering Applications Valentina Miguez-Pacheco, Alejandro A. Gorustovich, Aldo R. Boccaccini and Judith A. Roether, 336,
Chapter 16 Bioactive Glasses as Carriers of Therapeutic Ions and the Biological Implications Alexander Hoppe and Aldo R. Boccaccini, 362,
Chapter 17 Mesoporous Bioactive Glasses in Tissue Engineering and Drug Delivery Maria Vallet-Regi and Antonio J. Salinas, 393,
Chapter 18 Bioactive Glasses for Nerve Regeneration Giorgia Novajra, Francesco Baino, Stefania Raimondo, Joris Lousteau, Daniel Milanese and Chiara Vitale-Brovarone, 420,
Chapter 19 Bioactive Silicate Glass in Implantable Medical Devices: From Research to Clinical Applications Niko Moritz and Pekka K. Vallittu, 442,
Chapter 20 Glass Materials in Interventional Radiology and Interventional Oncology Sharon Kehoe, Nancy Kilcup, Robert Abraham and Daniel Boyd, 471,
Chapter 21 Sol-Gel-Derived Glasses for Bone Tissue Engineering William C. Lepry and Showan N. Nazhat, 496,
Subject Index, 522,


CHAPTER 1

Melt-derived Bioactive Silicate Glasses

SUSANNE FAGERLUND AND LEENA HUPA


1.1 Introduction

1.1.1 Glass – A Versatile Biomaterial

This chapter introduces some fundamental chemical and physical properties of glasses to be taken into account when designing and fabricating products based on bioactive glasses to be implanted inside the human body. The main emphasis is to explain the constraints to be taken into account from the materials science and chemical engineering points of view. The ultimate goal is to deliver the basic principles of glass science to serve as a platform for the various disciplines ranging from materials science to molecular biology, biochemistry, medicine, etc. The vision is that the steadily increasing multi-disciplinary experience provides the crucial knowledge needed for developing implants and scaffolds for controlled predetermined performance in the target application.

At first sight, the inherent brittle nature of glass does not make it a feasible material for implantable medical devices. At the same time, glass has several useful properties which support its utilization as a biomaterial. What is a biomaterial? Most biomaterials based on glasses or ceramics are designed to improve human health and the quality of life by restoring the function of living tissue and organs in the body. The single most important factor for a biomaterial is that it is able to be in contact with tissues of the human body without causing an unacceptable degree of harm to that body, i.e. the material is biocompatible. Recently, considerable research efforts have been directed to tailor highly porous tissue engineering scaffolds not only for bone tissue but also for emerging soft tissue applications. Detailed understanding of the nature and properties of glass provides a thorough basis for assessing its potential in prospective biomedical applications. In general, choice of a material for a particular application is based on its performance, properties, fabricability, and manufacturing costs.


1.1.2 Glass and Properties

Due to its amorphous structure glass possesses several features which make it an optimal material for manifold applications. Simplified, conventional inorganic glasses are homogeneous mixtures of oxides of alkalis, alkaline earths, aluminium, boron, silicon, etc. Most modern uses of these so-called soda lime glasses, including flat glass, hollowware glass and fibre glass, rely on the transparency to visible light combined with some other property, such as good mechanical strength, adequate chemical durability or electrical resistivity. Essentially, these commercial glass types are fabricated via the inexpensive melting route. They are easy to shape into various product forms at high temperatures when present as viscous liquids. In addition to the conventional glasses, specialty glasses possessing certain functional properties are essential in the modern everyday environment.

The functionality of the speciality glasses is often connected with the optical properties. Bioactive glasses used in contact with the living body as implants or as tissue engineering scaffolds belong to the family of speciality glasses. In contrast to most other applications, the transparency is not an essential property for the current applications of bioactive glass. Bioactivity of glasses may be defined in different ways, but common to all of these definitions is the requirement that the surface composition and morphology of the glasses change upon implantation. Simultaneously, the concentrations of the inorganic ions in the surrounding extracellular fluid change. Only glasses within certain limited composition range fulfil the requirements of bioactivity, i.e. show the desired interaction with the living tissue. Interestingly, whether it be transparency or the controlled surface reaction, the origin of the functionality of the glass is the same — the amorphous glass structure. As explained in Chapter 6 the amorphous glass structure enables adjusting the physical and chemical properties of glasses within certain limits merely by changing the constituent oxides or their ratios. This gives interesting possibilities to tailor the glass composition for various clinical...

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