Carbon-carbon bond formation is one of the most important topics in organic synthesis. One of the most powerful methods for constructing a carbon-carbon bond is the reductive coupling of carbonyl compounds giving 1,2-diols. Of these methods, the pinacol coupling, which was described in 1859, is still a useful tool for the synthesis of vicinal diols. 1, 2-Diols obtained in the reaction were very useful synthons for a variety of organic synthesis, and were also used as intermediates for the construction of biologically important natural product skeletons and asymmetric ligands for catalytic asymmetric reaction. This book reviews research done in the study of pinacol coupling, including recent applications of ultrasound in pinacol coupling reactions.
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Charlotte y Peter Fiell son dos autoridades en historia, teoría y crítica del diseño y han escrito más de sesenta libros sobre la materia, muchos de los cuales se han convertido en éxitos de ventas. También han impartido conferencias y cursos como profesores invitados, han comisariado exposiciones y asesorado a fabricantes, museos, salas de subastas y grandes coleccionistas privados de todo el mundo. Los Fiell han escrito numerosos libros para TASCHEN, entre los que se incluyen 1000 Chairs, Diseño del siglo XX, El diseño industrial de la A a la Z, Scandinavian Design y Diseño del siglo XXI.
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