Extrasynaptic GABAA Receptors (The Receptors, Band 27) - Softcover

Buch 20 von 29: The Receptors
 
9781493953219: Extrasynaptic GABAA Receptors (The Receptors, Band 27)
Softcover
ISBN 10: 1493953214 ISBN 13: 9781493953219
Verlag: Springer, 2016

Inhaltsangabe

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

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Von der hinteren Coverseite

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

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Verlag
Springer
Erscheinungsdatum
2016
Sprache
Englisch
ISBN 10 
1493953214
ISBN 13 
9781493953219
Einband
Taschenbuch
Anzahl der Seiten
308
Herausgeber
Errington Adam C., Di Giovanni Giuseppe, Crunelli Vincenzo
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Weitere beliebte Ausgaben desselben Titels

9781493914258: Extrasynaptic GABAA Receptors (The Receptors, 27, Band 27)

Vorgestellte Ausgabe

ISBN 10:  1493914251 ISBN 13:  9781493914258
Verlag: Springer, 2014
Hardcover