Assessment of Risk from Low-Level Exposure to Radiation and Chemicals: A Critical Overview - Softcover

Inhaltsangabe

Dedication.- Keynote Address.- Epidemiological Reservations about Risk Assessment.- Report of National Cancer Institute Symposium: Comparison of Mechanisms of Carcinogenesis by Radiation and Chemical Agents.- I. Common Molecular Mechanisms.- II. Cellular and Animal Models.- Theoretical Aspects.- What Are We Doing When We Think We Are Doing Risk Analysis?.- The Control of Mutagenesis and Cell Differentiation in Cultured Human and Rodent Cells by Chemicals That Initiate or Promote Tumor Formation.- The Role of Mechanistic Data in Dose-Response Modeling.- Statistical Aspects of the Estimation of Human Risks.- Biological Mechanisms: Single Cells.- The Isolation and Characterization of the Blym-1 Transforming Gene.- Retroviral Oncogenes and Human Neoplasia.- Mutation in Single-Cell Systems Induced by Low-Level Mutagen Exposure.- Quantitative Neoplastic Transformation in C3H/10T1/2 Cells.- Modification of the Response.- Risk Estimate for Genetic Effects.- Saturation of Repair.- Role of Tumor Promotion in Affecting the Multi-Hit Nature of Carcinogenesis.- Genetic and Epigenetic Aspects of Tumor Progression and Tumor Heterogeneity.- Biological Mechanisms: Cells to Animals.- Interaction of Ionizing Radiation and 8-Methoxypsoralen Photosensitization: Some Implications for Risk Assessment.- Low-Level Exposures to Chemical Carcinogens: Mutational End Points.- Radiogenic Neoplasia in the Thyroid and Mammary Clonogens: Progress, Problems and Possibilities.- Induction and Manifestation of Hereditary Cataracts.- The Human Experience: Models to Humans.- Extrapolation from Large-Scale Radiation Exposures: Cancer.- The Feasibility and Urgency of Monitoring Human Populations for the Genetic Effects of Radiation: The Hiroshima-Nagasaki Experience.- Prospects for Cellular Mutational Assays in Human Populations.- Cytogenetic and Allied Studies in Populations Exposed to Radiations and Chemical Agents.- Round Table Discussion.- Where the Future? Part I.- Where the Future? Part II.- Fons et Origo.- The Agent Carrier and Transfer Approach to Radiobiological Responses.- Participants 507.

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