Biochemistry of Biogenic Amines (Section I: Basic Neuropharmacology, Band 3) - Softcover

Biochemistry of Biogenic Amines

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Inhaltsangabe1 Enzymes Involved in the Biosynthesis and Degradation of Catecholamines.- 1. Catecholamine Biosynthesis.- 2. Enzymes Involved in the Biosynthesis of Catecholamines.- 2.1. Tyrosine Hydroxylase.- 2.2. Dihydropteridine Reductase.- 2.3. Dopa Decarboxylase.- 2.4. Dopamine- -hydroxylase.- 2.5. Phenylethanolamine-N-methyltransferase.- 3. Enzymes Involved in Catabolism of Catecholamines.- 3.1. Monoamine Oxidase.- 3.2. Catechol-O-methyltransferase.- 4. References.- 2 Release of Catecholamines.- 1. Introduction.- 2. Release From Adrenergic Neurons.- 2.1. Anatomical and Physiological Characteristics of Adrenergic Nerves.- 2.2. Mechanisms of Release: The Exocytosis Hypothesis.- 2.3. Importance of Ca2+ in Release; Effects of Other Ions.- 2.4. Regulation of Release.- 2.5. Pharmacological Aspects of the Storage and Release of NE.- 2.6. False Neurotransmitters.- 3. Release from Central Adrenergic Neurons.- 3.1. Release from the Brain in Vivo.- 3.2. Release from CNS Tissues in Vitro.- 4. Conclusions.- 5. References.- 3 Properties and Functions of Intraneuronal Monoamine Compartments in Central Aminergic Neurons.- 1. Introduction.- 2. One or Several Storage Compartments for Monoamines .- 3. Utilization of Monoamines in Aminergic Terminals.- 3.1. Disappearance Curves for Radioactive Monoamines.- 3.2. Initial Accumulation of Newly Synthesized Amines.- 3.3. Initial Rate of Disappearance of Catecholamines After Inhibition of Their Synthesis.- 4. Relation of Storage Compartments to Amine Release.- 4.1. Noradrenergic Neurons.- 4.2. Serotoninergic Neurons.- 4.3. Dopaminergic Neurons.- 5. Functional Implications of Storage Compartments in Aminergic Neurons.- 5.1. Effects of Reserpine.- 5.2. Effects of Synthesis Inhibitors.- 6. Conclusions.- 7. References.- 4 5-Hydroxytryptamine and Other Indoles in the Central Nervous System.- 1. Occurrence of 5-Hydroxytryptamine in Central Nervous System.- 2. Pathway of 5-Hydroxytryptamine Synthesis.- 2.1 Tryptophan 5-Hydroxylation.- 2.2. 5-Hydroxytryptophan Decarboxylase.- 3. Pathways of 5-Hydroxytryptamine Metabolism.- 3.1. Monoamine Oxidase.- 3.2. Aldehyde Dehydrogenase and Reductase.- 3.3. O-Sulfate Conjugation.- 4. Metabolic Control of 5-Hydroxytryptamine.- 4.1. Free and Bound Plasma Tryptophan.- 4.2. Tryptophan Transport into the Brain.- 4.3. Turnover: Methodology and Relevance.- 4.4. Control of 5-Hydroxytryptamine Concentrations by Monoamine Oxidase.- 4.5. Control of Brain 5-HT Synthesis, Concentrations, and Turnover.- 4.6. Summary.- 5. Function of 5-Hydroxytryptamine.- 5.1. Evidence for Release and Role in Synaptic Transmission.- 5.2. Role of 5-Hydroxytryptamine in Behavior and Physiological Systems.- 6. Effects of Drugs on Turnover and Function of 5-Hydroxytryptamine.- 6.1. 5,6- and 5,7-Dihydroxytryptamine.- 6.2. Corticosteroids, -Methyltryptophan, and Stress.- 6.3. Lithium.- 6.4. Morphine.- 6.5. Tricyclic Antidepressant Drugs.- 6.6. Hallucinogenic Drugs.- 6.7. Electroconvulsive Shock.- 6.8. Reserpine and Tetrabenazine.- 6.9. Chlorpromazine.- 7. 5-Hydroxytryptamine in Mental Illness and Neurological Disease.- 7.1. Indoleamines and Schizophrenia.- 7.2. 5-HT and Affective Disorders.- 7.3. 5-HT and Mongolism.- 7.4. 5-HT and Phenylketonuria.- 8. Other Indoleamines in the Central Nervous System.- 8.1. Melatonin, 5-Methoxytryptamine, and N-Methylation inCNS.- 8.2. Tryptamine.- 9. References.- 5 Biochemistry of Cholinergic Neurons.- 1. Introduction.- 1.1. Cholinergic Systems.- 1.2. Physiology of Cholinergic Transmission.- 2. Biochemical Components.- 2.1. Acetylcholine.- 2.2. Choline Transport.- 2.3. Choline Acetyltransferase.- 2.4. Acetylcholinesterase.- 3. Subcellular Organization.- 3.1. Fractionation of Cholinergic Synapses.- 3.2. Synthesis of Acetylcholine.- 3.3. Release of Acetylcholine.- 3.4. Inactivation of Acetylcholine.- 4. Pharmacology.- 4.1. Drugs Affecting Acetylcholine Concentration.- 4.2. Acetylcholine and Higher Function.- 5. Conclusion. Artikel-Nr. 9781468431735

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