Mechanisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment - Softcover

Inhaltsangabe

to Mechanisms of DNA Damage and Repair.- History of Radiation Biology from a Personal Point of View.- DNA Damage.- Mechanisms of Damage.- Comparison of Mechansms for DNA Strand Break Formation by the Direct and Indirect Effect of Radiation.- Eletron Spin Resonance Studies of the Mechanism of Radiation Damage to DNA.- Free Radical Mechanisms of DNA Base Damage.- Peroxyl Radicals of Nucleic Acids and Their Components.- Radiation-Induced Peroxidation of DNA and Effects of Redox-Active Agents.- The Radiation Chemistry of the Purine Bases Within DNA and Related Model Compounds.- Bacteriophage DNA as a Model for Correlation of Radical Damage to DNA and Biological Effects.- Damage in Cells.- Ultrafast Chemical Repair of DNA Single and Double Strand Break Precursors in Irradiated V79 Cells.- Assessment of DNA Damage by Filter Elution Assays.- DNA Modification by Sulfur Mustards and Nitrosoureas and Repair of These Lesions.- Intragenomic Localization of Carcinogen-DNA Damage.- Ionizing Radiation Induced DNA Damage: Identities and DNA Repair.- Effects of LET? on the Fate of DNA Damage Induced in Rabbit Sensory Cells In Situ: Fundamental Aspects.- Radiation Damage to DNA in Various Animal Tissues: A Comparison of Yields and Repair In Vivo and In Vitro.- Differential Regulation of Base and Nucleotide Excision Repair in Mammalian Cells.- Immediate and Repair Induced DNA Double Strand Breaks in Mammalian Cells.- DNA-Protein Cross-Links: New Insights into their Formation and Repair in Irradiated Mammalian Cells.- DNA-to-Protein Crosslinks and Backbone Breaks Caused by Far-and Near-Ultraviolet and Visible Light Radiations in Mammalian Cells.- DNA Binding Drugs.- Sequence Specificity and Biological Consequences of Drugs that Bind Covalently in the Minor Groove of DNA.- Molecular Recognition of DNA Binding Agents: High-Field 1H and 31P One- and Two-Dimensional NMR Studies on the 1:1 Intercalation Complexes of Mitoxantrone with selected Oligodeoxyribonucleotides.- DNA Binding and Biological Properties of Bis and Tris Intrcalating Molecules.- Novel Types of DNA-Sugar Damage in Neocarzinostatin Cytotoxicity and Mutagenesis.- DNA-Drug Binding and Control of Genetic Information.- Computer-Aided Design of New DNA Intercalators.- DNA Repair and Consequences.- Differential Expression of SOS Genes in an E. Coli Mutant Producing Unstable LexA Protein Enhances Excision Repair But Inhibits Mutagenesis.- Mutagenic DNA Repair in Bacteria: The Role of UmuDC and MucAB.- The Repair of Pyrimidine Dimers Via a DNA-Glycosylase Mechanism.- The Involvement of an E. Coli Multiprotein Complex in the Complete Repair of UV-Damaged DNA.- Pyrimidine Dimer Induced Alteration of DNA Tertiary Structure Evidence for Unwinding and Shortening.- Mismatch Correction.- Molecular Approaches to the Study of Nucleotide Excision Repair in Eukaryotes.- Restoration of DNA Repair in UV-Sensitive Chinese Hamster Ovary Cell by the denV Gene from Bacteriophage T4.- The Adaptive Response of Mammalian Cells to Alkylating Agents.- DNA Glycosylases in DNA Repair.- Apurinic Sites as Common Intermediates in Mutagenesis.- The Repair of Uracil-Containing DNA.- Metabolic Consequences of DNA Damage: The Role of Poly (ADP-Ribose) Polymerase as Mediator of the Suicide Response.- DNA Damage, DNA Repair and Induced Mutagenesis: Some Enzymological and Structural Considerations.- Mechanisms of Mutagenesis of E. Coli by Ultraviolet Light.- Activation of H-ras-1 Oncogenes by Chemical Carcinogens.- Activation of the c-myc Oncogene.- Salmonella Tester Strains: Mutational Targets and Correlation with Animal Carcinogenicity and Teratogenicity.- Mechanisms of Spontaneous Mutagenesis: Clues from Mutational Specificity.- Risk Assessment.- Use of Gradient Denaturing Gels to Determine Mutational Spectrum in Human Cells.- Urinary N-Nitrosamino Acids as Indices of Endogenous Formation of N-Nitroso Compounds.- Application of Monoclonal Antibodies to Monitor Human Exposure to Aflatoxin Bl.- Blood Proteins as Carcinogen D

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