Immunodermatology - Softcover

Inhaltsangabe

1 Cell-Mediated Immunity.- 1. Introduction.- 2. Cellular Immune Function.- 2.1. T-Cell Immunity.- 2.2. The Primary Response.- 2.3. The Secondary Response.- 2.4. Lymphocyte Subpopulations.- 3. Lymphocyte Activation in Vitro.- 3.1. Parameters of Activation.- 3.2. Lymphocyte Stimulators.- 3.3. Process of Activation.- 3.4. Lymphocyte Mediators.- 4. References.- 2 Antigens and Immunogens.- 1. Introduction.- 2. Properties of Antigenic Determinants.- 2.1. Size.- 2.2. Specificity.- 2.3. Forces Binding Antigen to Antibody.- 2.4. Conformation.- 2.5. Cross-Reactions.- 3. Immunogens.- 3.1. Foreignness.- 3.2. Size.- 3.3. Requirement for Multivalence.- 3.4. Genetic Control.- 4. Allergens.- 5. Autoantigens.- 6. References.- 3 Humoral Immunity in Comprehensive Immunology.- 1. Introduction.- 2. Antibody Structure and Function.- 2.1. General Characteristics.- 2.2. Conformation of Immunoglobulins.- 3. Structure and Biological Function of the Antibodies.- 3.1. Immunoglobulin G.- 3.2. Immunoglobulin M.- 3.3. Immunoglobulin A.- 3.4. Immunoglobulin D.- 3.5. Immunoglobulin E.- 4. The B-Cell System.- 5. B-Cell Activation.- 6. Immunoglobulin Synthesis and Secretion.- 7. Evolution of the Immunoglobulins.- 8. References.- 4 The Complement System: Mechanisms of Action, Biology, and Participation in Dermatological Diseases.- 1. Introduction.- 2. Biochemistry of Complement: Activation Mechanisms.- 2.1. Classical Complement Reaction.- 2.2. Alternative and Amplification Pathways of Complement Activation.- 3. Roles of "Control" Proteins in the Complement System.- 3.1. Inhibitor of the Activated First Component (C?) of Complement (C?INH).- 3.2. The C3b Inactivator (C3bINA)-Control Protein of C3b and C4b.- 3.3. An Inactivator of the C3a and C5a Anaphylatoxins (AI).- 4. Biological Activity of Some Products of the Complement System.- 5. Evaluation of the Complement System.- 6. Laboratory Measurement of Complement.- 6.1. Collection of Samples.- 6.2. Functional Hemolytic Assays.- 6.3. Immunochemical Assays for Complement Proteins.- 6.4. Additional Complement Assays.- 7. Complement Abnormalities in Skin Diseases.- 8. Inborn Deficiencies of the Complement System.- 8.1. Deficiencies of Components.- 8.2. Deficiencies of Control Proteins.- 9. Acquired Abnormalities of the Complement System Associated with Skin Diseases.- 9.1. Angioedema and Urticaria.- 9.2. Complement Abnormalities in Cutaneous Vasculitis.- 9.3. Complement Abnormalities in Infectious Processes with Skin Manifestations.- 9.4. Uncommon Cutaneous Disorders Associated with Complement Abnormalities.- 9.5. Autoimmune Processes Involving the Skin Associated with Complement Abnormalities.- 9.6. Inflammatory Processes Involving the Skin Associated with Complement Abnormalities.- 10. Conclusions.- 11. References.- 5 Mechanisms of Nonspecific Host Resistance.- 1. Introduction.- 2. Methods for Measurement of Inflammatory Cell Accumulation and Chemotaxis.- 3. Chemotactic Factors.- 3.1. C-Derived Chemotactic Factors.- 3.2. Cell-Derived Chemotactic Factors.- 3.3. Bacterial Chemotactic Factors.- 4. Mechanisms of Chemotaxis.- 5. Phagocytosis.- 6. Summary.- 7. References.- 6 The HLA System and Dermatological Diseases.- 1. Introduction.- 2. HLA System.- 2.1. HLA-A, -B, -C.- 2.2. HLA-D and -DR.- 3. Genetics of HLA.- 4. HLA Genetic Linkage Group.- 5. HLA and Disease.- 5.1. Introduction.- 5.2. Statistical Considerations and Experimental Design.- 5.3. HLA and Dermatological Diseases.- 5.4. HLA-Linked Diseases.- 6. Conclusions.- 7. References.- 7 Natural Control over Immune Responses.- 1. Introduction.- 2. Immunological Enhancement.- 2.1. Role of Lymphocytes.- 2.2. Role of Monocytes and Macrophages.- 3. Suppressor Cells and Activities.- 3.1. Animal Models.- 3.2. Studies in Man.- 3.3. Soluble Suppressor Factors.- 4. Lymphokines.- 5. Immunological Memory.- 5.1. B-Cell Memory.- 5.2. T-Cell Memory.- 6. Immune Tolerance.- 6.1. B-Cell Tolerance.- 6.2. T-Cell Tolerance.- 6.3. Role of Other Cells in Tolerance.- 6.4. Role of Antibody an

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