A Case Approach to Perioperative Drug-Drug Interactions - Softcover

Inhaltsangabe

Part I. Introduction to Drug-Drug Interactions

1. Let's Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions

F. Jacob Seagull, PhD, Catherine Marcucci, MD

2. Pharmacodynamic Interactions: Core Concepts

Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

3. Pharmacokinetic Interactions: Core Concepts

Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc

4. A Brief Treatise On The Area Under The Curve

Michael J. Sikora, MD, Barbara Jericho, MD

Part II. Introduction to Drug-Drug Interactions: Brief Review of CYP450 Enzymes, UGTs, and Transporters

5. CYP2D6: Where It All Began

John C. Sanders, MBBS, FRCA, Rachel Koll, MD, Randal O. Dull, MD, PhD

6. CYP2E1: The Anesthesia Enzyme

Benjamin S. Gmelch, MD, Randal O. Dull, MD, PhD

7. CYP3A4: The Workhorse

Jennifer DeCou, MD, Nathaniel Birgenheier, MD, Randal O. Dull, MD, PhD

8. CYP1A2: The Switch-hitter

Danielle Roussel, MD, Emily Hagn, MD, Randal O. Dull, MD, PhD

9. CYP2B: 2B or Not 2B?

Dustin Coyle, MD, Randal O. Dull, MD, PhD

10. CYP2C9: The Support Crew I

Byron Douglas Fergerson, MD, Crystal B. Wallentine, MD, Randal O. Dull, MD, PhD

11. CYP2C19: The Support Crew II

Barbara Jericho, MD, Alfredo Aguiar, MD, Randal O. Dull, MD, PhD

12. UGTs: Conjugating Cousins

Neil B. Sandson, MD

13. The Cytochrome P450 System In Disease States-A Brief Review

Catherine Marcucci, MD

PART III. Drug-Drug Interactions: Paradigms and Core Concepts

14. P-glycoprotein and OATP Transporters

Dustin Coyle MD, Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD

15. The "Fatal" Forty

Neil B. Sandson MD, Michael Hutchens MD, F. Jacob Seagull, PhD, Catherine Marcucci, MD

16. The Six Patterns of Pharmacokinetic Drug-Drug Interactions

Neil B. Sandson, MD, Catherine Marcucci, MD

17. The Problem with the Drug-Drug Interaction Software: A Procrustean Dilemma

Neil B. Sandson, MD, F. Jacob Seagull, PhD, Wayne T. Nicholson, MD, PharmD, MSc, Catherine Marcucci, MD

18. Pharmacogenomics

Chad D. Moore, PhD, William Hartman, MD, PhD, Michael Hutchens, MD, Randal O. Dull, MD, PhD

19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important

Joseph A. Lovely, PharmD, BCPS, Stephen Esper, MD, MBA, Michael Hutchens, MD, Wayne T. Nicholson, MD, PharmD, MSc, Catherine Marcucci, MD

20. The Lawyers Can Read, Too: Case Presentations from the Courtroom

Jessica Voge, MD, David K. Miller, JD

Part IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents

21. Introduction

Catherine Marcucci, MD

22. That Sums It Up

Volatile anesthetics, additive MACs

James A. Jernigan, MD, James W. Ibinson, MD, PhD

23. 1+1+1+1=?

Variable effects of combined substances

Anthony T. Silipo, DO, Raymond M. Planinsic, MD, Erica D. Wittwer, MD, PhD, Juraj Sprung MD,PhD, Wayne T. Nicholson, MD, PharmD, MSc

24. A Delayed Surgeon Is A "Dismayed" Surgeon?

Nitrous oxide, dexmedetomidine, somatosensory evoked potentials

Jonathan Anson, MD

25. Relax, It's Only Gentamicin

Volatile anesthetics, aminoglycoside antibiotics, neuromuscular junction

Brian Gierl, MD, Ferenc E. Gyulai, MD

26. Jaundice After Surgery

Halothane hepatitis, CYP2E1

Jonathon E. Kivela, MD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD

27. Everybody Clear?

Halothane, epinephrine arrhythmia

Nikhli Patel, MD, Barbara Jericho MD, Randal O. Dull, MD, PhD

28. The Hemodynamic Hole

general anesthetics, ACE-I, ARBs

Arun L. Jayaraman, MD, PhD, Theresa A. Gelzinis, MD

29. Alpha-2 To The Rescue But Beware Bradycardia

volatile anesthetics, alpha-2 agents

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