Microdialysis in Drug Development (AAPS Advances in the Pharmaceutical Sciences Series, 4, Band 4) - Hardcover

Buch 3 von 38: AAPS Advances in the Pharmaceutical Sciences
 
9781461448143: Microdialysis in Drug Development (AAPS Advances in the Pharmaceutical Sciences Series, 4, Band 4)
Hardcover
ISBN 10: 146144814X ISBN 13: 9781461448143
Verlag: Springer, 2012

Inhaltsangabe

A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.

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Über die Autorin bzw. den Autor

Prof. Markus Müller, MD is Head of the Department of Clinical Pharmacology at the Medical University of Vienna in Austria. He is specialized in Internal Medicine and Clinical Pharmacology and is an international expert in clinical research. He has published over 80 articles on the use and methodology of microdialysis in clinical drug development.

Von der hinteren Coverseite

In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.

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Verlag
Springer
Erscheinungsdatum
2012
Sprache
Englisch
ISBN 10 
146144814X
ISBN 13 
9781461448143
Einband
Gebundene Ausgabe
Anzahl der Seiten
352
Herausgeber
Müller Markus
Kontakt zum Hersteller
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Deutschland

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9781489996213: Microdialysis in Drug Development (AAPS Advances in the Pharmaceutical Sciences Series, Band 4)

Vorgestellte Ausgabe

ISBN 10:  1489996214 ISBN 13:  9781489996213
Verlag: Springer, 2014
Softcover