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Molecular Epidemiology: Applications in Cancer and Other Human Diseases - Hardcover

 
9781420052916: Molecular Epidemiology: Applications in Cancer and Other Human Diseases
Hardcover
ISBN 10: 1420052918 ISBN 13: 9781420052916
Verlag: CRC Press, 2013

Inhaltsangabe

This volume comprises the investigation of factors that may predict the response to treatment, outcome, and survival by exploring:

• design considerations in molecular epidemiology, including:

  • case-only
  • family-based
  • approaches for evaluation of genetic susceptibility to exposure and addiction pharmacogenetics
  • incorporation of biomarkers in clinical trials

• measurement issues in molecular epidemiology, including

  • DNA biosampling methods
  • principles for high-quality genotyping
  • haplotypes
  • biomarkers of exposure and effect
  • exposure assessment

• methods of statistical inference used in molecular epidemiology, including

  • gene-gene and gene-environment interaction analysis
  • novel high-dimensional analysis approaches
  • pathway-based analysis methods
  • haplotype methods, dealing with race and ethnicity
  • risk models
  • a discussion of reporting and interpreting results

• A specific discussion and synopsis of these methods provides concrete examples drawn from primary research in cancer

Covering design considerations, measurement issues, and methods of statistical inference, and filled with scientific tables, equations, and pictures, Molecular Epidemiology: Applications in Cancer and Other Human Diseases presents a solid, single-source foundation for conducting and interpreting molecular epidemiological studies.

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Über die Autorin bzw. den Autor

TIMOTHY R. REBBECK is Professor of Epidemiology, Director of the Center for Genetics and Complex Traits, and Associate Director for Population Science of the Abramson Cancer Center at the University of Pennsylvania in Philadelphia. Dr. Rebbeck received his Ph.D. from the University of Michigan, Ann Arbor, and has written over 150 peer-reviewed articles.

CHRISTINE B. AMBROSONE is Chair, Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York. Dr. Ambrosone received her Ph.D. from the Roswell Park Cancer Institute, State University of New York at Buffalo, and has written over 115 peer-reviewed articles.

PETER G. SHIELDS is Professor of Medicine and Oncology Interim Academic Chair, Department of Medicine Deputy Director, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC. Dr. Shields received his M.D. Medical Doctor, Mount Sinai School of Medicine, New York, New York, and has written over 140 peer-reviewed articles.

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Verlag
CRC Press
Erscheinungsdatum
2013
Sprache
Englisch
ISBN 10 
1420052918
ISBN 13 
9781420052916
Einband
Gebundene Ausgabe
Auflage
1
Anzahl der Seiten
302
Herausgeber
Rebbeck Timothy R., Ambrosone Christine B., Shields Peter G.
Kontakt zum Hersteller
CRC Press
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