The Journal of Infectious Diseases, Vol. 12: Published by the Memorial Institute for Infectious Diseases (Classic Reprint) - Softcover

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Excerpt from The Journal of Infectious Diseases, Vol. 12: Published by the Memorial Institute for Infectious Diseases

In the work by Dr. Carlson and myself on the distribution of antibodies in the body fluids of dogs,' we found that in dogs, injected with rat blood, opsonin for rat corpuscles appeared in the cerebrospinal fluid, which, however, did not contain a trace of agglutinin. In the serum of the blood and the lymph, both these antibodies described parallel curves. The curve of the opsonin concentration in the cerebrospinal fluid described exactly the same course as in the blood and lymph, but remained much lower. In Chart 1 are reproduced composite curves showing these relations and obtained from estimations on dogs killed at varying intervals after the intravenous injection of one cubic centimeter of 10 per cent suspension of rat blood per kilo of the weight of dog.

In dogs injected intravenously with goat blood we did not find any agglutinin in the cerebrospinal fluid. During the period of highest antibody content in the blood and lymph, however, the fluid contained traces of lysin and opsonin.

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