Excerpt from Science Progress, Vol. 2
Martin made most of his observations on dogs, but obtained confirmatory results on other animals (cats and rabbits). He found that different doses produced different results. Immediately after the introduction of the venom the coagulability of the blood increases; and this increase in the case of moderate or large doses (more than 00001 gramme per kilo. Of body weight) culminates in intravascular clotting of greater or less extent. The injection of smaller doses produces a transient phase of increased coagulability, but after two minutes this is succeeded by a negative phase the blood drawn either fails to clot at all, or does so only after the lapse of several hours. The thrombosis occurs more readily in venous than arterial blood, and is frequently confined to the portal area.
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