In order to help people make their own assessment of a published manuscript or the risk assigned to a family member, Bridge (medical genetics and pathology, U. of Calgary) explains the fundamentals of how geneticists start with laboratory results and end up with a number representing genetic risk. He avoids abstract equations in favor of worked examples using numbers instead of symbols. Without trying to provide an example of every possible scenario, he offers principles and techniques by which readers can make their own adaptations. His revisions from the 1994 edition include a new discussions of haploid risk calculation, cancer-specific testing, and DNA polymorphisms to test paternity and analyze zygosity. Includes a glossary without pronunciation. Annotation c. by Book News, Inc., Portland, Or.
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Peter J. Bridge is director of the Molecular Diagnostic Laboratory at Alberta Children's Hospital in Calgary, Alberta, Canada.
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