Sequence Alignment: Methods, Models, Concepts, and Strategies - Softcover

9780520271319: Sequence Alignment: Methods, Models, Concepts, and Strategies

Softcover

ISBN 10: 0520271319 ISBN 13: 9780520271319

Verlag: University of California Press, 2011

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Rese�a del editor

The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences - making sure that sequences from one source are properly compared to those from other sources - remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted. Edited by Michael S. Rosenberg with essays by many of the field's leading experts, Sequence Alignment covers molecular causes, computational advances, approaches for assessing alignment quality, and philosophical underpinnings of the algorithms themselves.

Nota de la solapa

"Sequence alignment represents the final frontier in the development of repeatable, comprehensive methods for phylogenetic analysis. This book will inform readers about the current status of alignment methods and will help stimulate additional work in the field."—David M. Hillis, University of Texas

"Sequence Alignment provides an in-depth treatment of the prerequisite to many evolutionary analyses by presenting a diversity of opinions on the best way to align complex molecular sequence data. Topics covered include the basic algorithms used, global versus local procedures, the robustness alignment error detection, and a description of the programs now available. Sequence Alignment is a reassuring companion, guiding the reader through a large and complicated field."—John Huelsenbeck, Department of Integrative Biology, University of California, Berkeley

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