Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures.
This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on society.
Set within a wide historical, social and cultural context, it provides expanded coverage of pre-twentieth century drugs, the huge advances made in the twentieth century and the latest developments in drug research.
From the reviews:
"...an excellent bibliographic resource for those interested in the background papers that serve as the foundation for discovery of specific drug entities." JOURNAL OF MEDICAL CHEMISTRY, June 2006
"...a very comprehensive overview of drug development. It should be on the shelf on any aspiring pharmacist, medicinal chemist, or person interested in the history of therapeutic agents." JOURNAL OF CHEMICAL EDUCATION, February 2006
"...a very readable and closely researched book..." CHEMISTRY & INDUSTRY, October 2005
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The process of discovery of medicinal compounds has evolved over millennia, from Neanderthal man’s use of medicinal herbs to the highly-evolved techniques of biotechnology and high-throughput screening used by today’s medicinal chemists. Drug Discovery – A History reviews the full panoply of discovery of therapeutic compounds in use today.
The book is divided into three parts. The first, the Legacy of the Past, gives an overview of medicinal compounds in society, ranging from the earliest use of medicinal herbs through the ancient civilisations in Mesopotamia, Egypt, Greece, and Rome, concluding with an overview of development of life-saving organic compounds in the 20th century. The second part examines the commonest source of the drug – the natural world. Prototypes from vegetable, animal, and microbial sources are described in separate chapters, as are the medicinal compounds prepared from them. The problem of relying on nature as a source of drug prototypes is confronted. Part Three considers synthetic compounds that have served as drug prototypes, the role of serendipity in providing these synthetic prototypes, and a review of compounds derived from them.
Drug Discovery – A History is essential reading for medicinal chemists, pharmacologists, organic chemists, physicians, researchers and anyone with an interest in the development of therapeutic drugs.Review:
"This is a book that belongs in the personal library of every medicinal chemist, pharmacist, and all others interested in drug discovery and the historical basis of medicinal chemistry." (Journal of Medicinial Chemistry, August 10, 2006)
"...an entertaining as well educationally enlightening read." (Bulletin of the History of Chemistry, Volume 31, Number 2, 2006)
"...a valuable source of information and an enjoyable review of the age of synthetic chemistry with its great therapeutic success." (American Journal of Therapeutics, March/April 2006)
"...a very comprehensive overview of drug development. It should be on the shelf on any aspiring pharmacist, medicinal chemist, or person interested in the history of therapeutic agents." (Journal of Chemical Education, February 2006)
"...a thoroughly enjoyable book to read, to use as reference, or to jump into at any point. It is a must addition for the libraries of...anyone who wishes to know more about the drug discovery process and how it has evolved over time." (The Annals of Pharmacotherapy, December 2005)
"...will be of great value to medicinal chemists, pharmacologists, physicians, researchers and everyone interested in the development of therapeutic drugs." (The Chemical Educator, Vol. 10, No. 3., 2005)
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