Proteomics for Biological Discovery: The Post-Genomic Challenge - Softcover

Über die Autorin bzw. den Autor

TIMOTHY D. VEENSTRA, PhD, is the Director of the Laboratory of Proteomics and Analytical Technologies, National Cancer Institute-Frederick, Frederick, Maryland. JOHN R. YATES III, PhD, is in the Department of Cell Biology, The Scripps Research Institute, La Jolla, California.

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Tools and guidance from a team of experts to meet the challenges of the post-genomics era

Proteomics for Biological Discovery presents the state of the art in the field of proteomics and offers readers new tools and techniques to advance their own research. Moreover, the publication provides readers with an understanding of new and emerging directions for proteomics research and applications.

The publication begins with an introduction that examines the rise of proteomics and discusses potential benefits, such as new diagnostics and therapeutics, that further proteome-level research promises. Next, the publication is divided into three sections:

• Foundations of Proteomics
• Functional Proteomics
• Novel Approaches in Proteomics

All the tools of proteomics, from conventional to novel techniques, are examined, including:

• Proteomic analysis using 2D-PAGE
• Gel-free proteomics to measure protein abundances
• Characterization of intact noncovalent protein complexes
• Three-dimensional protein structure determination
• Protein localization by imaging techniques
• Protein arrays

The publication also covers key foundations of proteomics: separations, bioinformatics, and automation. Each chapter, written by an expert, addresses technological limitations, emerging approaches, and key questions requiring further investigation. In addition, each chapter explores future applications for industry and basic science.

This reference brings readers in touch with a team of experts who are leading the proteomics revolution. It is, therefore, recommended for students and researchers across the gamut of fields in biomedical research, including biochemistry, protein chemistry, molecular genetics, cell and developmental biology, and bioinformatics.