Microbial Functional Genomics - Hardcover

Über die Autorin bzw. den Autor

Jizhong Zhou is a Staff Scientist and science leader for the Microbial Genomics and Ecology section in the Environmental Sciences Division of Oak Ridge National Laboratory. He is the author of more than 50 publications on molecular biology, microbial genomics, molecular evolution, microbial ecology, bioremediation, and theoretical ecology.

Ying Xu is the group leader of the computational protein structure group of Life Sciences Division of Oak Ridge National Laboratory. He serves on a number of scientific review committees including the NIH review panel on structural genomics.

James M. Tiedje is University Distinguished Professor of Microbial Ecology and Director of the National Science Foundation Center for Microbial Ecology at Michigan State University. He is a Fellow of ASA, SSSA, AAAS, the International Institute of Biotechnology and a Fellow of the American Academy of Microbiology.

Dorothea Thompson is currently a Research Staff Scientist in the Environmental Sciences Division at Oak Ridge National Laborat ory (ORNL), working in the area of microbial functional genomics. She received her Ph.D. in molecular microbiology from The Ohio State University (Columbus, OH) and master’s degrees from Virginia Tech and the Pennsylvania State University. Dr. Thompson pursued postdoctoral training in bacterial pathogen typing and vaccine development at the U. S. Food and Drug Administration in Bethesda, Maryland, and in DNA microarray-based gene expression analysis at ORNL before becoming a staff member in 2002. Her research interests and expertise focus on the mechanisms of transcription regulation in prokaryotic systems and the use of genomic technologies, specifically DNA microarrays, to describe the molecular basis underlying cellular adaptation to environmental stresses.

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The completion of sequences for over one hundred microbial genomes, with more than 200 additional projects now under way, has vastly multiplied the potential avenues for research using genetic, biochemical, and bioinformatics tools, and has created the new field of functional genomics. These advances have laid the foundation for understanding key principles applicable to human genome research.

Microbial Functional Genomics, the first comprehensive treatment of this subject, provides a much-needed synthesis of genome-wide studies on gene networks and functions, as well as the use of genomic data and technology in addressing a host of biological problems. Topics covered include:

• Genomics: introduction, history, and current challenges and scope
• Microbial diversity and evolution from a genomics perspective
• Computational methods for genome annotation and functional prediction of genes
• DNA microarray technology and its application to gene expression data analysis, mutation analysis, and microbial detection
• Mutagenesis as a genomic tool for studying gene function
• The functional genomics of model organisms, bacterial pathogens, and environmentally significant microorganisms
• The impact of genomics on antimicrobial drug discovery and toxicology

Microbial Functional Genomics represents a timely summary of the principles, approaches, and applications at the forefront of this exciting and rapidly progressing field.

Aus dem Klappentext

The completion of sequences for over one hundred microbial genomes, with more than 200 additional projects now under way, has vastly multiplied the potential avenues for research using genetic, biochemical, and bioinformatics tools, and has created the new field of functional genomics. These advances have laid the foundation for understanding key principles applicable to human genome research.

Microbial Functional Genomics, the first comprehensive treatment of this subject, provides a much-needed synthesis of genome-wide studies on gene networks and functions, as well as the use of genomic data and technology in addressing a host of biological problems. Topics covered include:

• Genomics: introduction, history, and current challenges and scope
• Microbial diversity and evolution from a genomics perspective
• Computational methods for genome annotation and functional prediction of genes
• DNA microarray technology and its application to gene expression data analysis, mutation analysis, and microbial detection
• Mutagenesis as a genomic tool for studying gene function
• The functional genomics of model organisms, bacterial pathogens, and environmentally significant microorganisms
• The impact of genomics on antimicrobial drug discovery and toxicology

Microbial Functional Genomics represents a timely summary of the principles, approaches, and applications at the forefront of this exciting and rapidly progressing field.