The AH Receptor in Biology and Toxicology

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9780470601822: The AH Receptor in Biology and Toxicology

This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.

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From the Back Cover:

The complete guide to the aryl hydrocarbon receptor (AHR)—what it is, what it does, and what it might mean for the future of drug metabolism

Providing a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the induction of drug-metabolizing enzymes and diverse toxicities caused by dioxins, The AH Receptor in Biology and Toxicology is essential reading for toxicologists, chemists, biologists, pharmacologists, and other experts studying drug metabolism.

Evidence suggests that the AHR protein imparts important physiological functions that place it at the crossroad of biology and toxicology, making it the focus of extensive research activity. Examining the unique dual role of AHR as both a toxicant and a factor in biological processes, this comprehensive reference work covers the full spectrum of AHR topics from basic concepts, toxicological risk analysis, and models, to polymorphisms and related diseases. Addressing epigenetic mechanisms, gene expression, reproductive/developmental toxicity, signal transduction, and transgenic animal models, the book runs the gamut of AHR knowledge.

With contributions from renowned international experts, The AH Receptor in Biology and Toxicology puts the forefront of AHR research at your fingertips.

About the Author:

Raimo Pohjanvirta, PhD, is Professor of Toxicology at the University of Helsinki. He has been studying the effects and action mechanisms of dioxins for over twenty years, publishing over a hundred peer-reviewed papers on dioxins and AHR. Dr. Pohjanvirta has been an invited lecturer at major international conferences, including the Society of Toxicology, EUROTOX, and the British Toxicology Society.

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