Galectins - Hardcover

Über die Autorin bzw. den Autor

Anatole A. Klyosov, PhD, is Chief Scientist and cofounder of Pro-Pharmaceuticals, Inc. He has published more than 290 peer-reviewed articles in scientific journals; authored and edited books on enzymes, carbohydrates, and biotechnology, including Wood-Plastic Composites (Wiley); and holds thirty-nine patents.

Zbigniew J. Witczak, PhD, has extensive industrial and academic experience in carbohydrates. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award of the ACS Division of Carbohydrate Chemistry for his outstanding research contribution to carbohydrate chemistry and service to the division.

David Platt, PhD, is Chief Executive Officer and cofounder of Pro-Pharmaceuticals, Inc. He has published peer-reviewed articles and holds many patents, primarily in the field of carbohydrate chemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACS symposium book Carbohydrate Drug Design.

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This is the first book specifically on galectins―a challenging and promising area in medical biochemistry and drug design. After an introduction to galectins, the book covers their structure and functions, ligand specificity, and molecular mechanisms of action, along with the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity. Then it covers the effect of galectins on cell migration, angiogenesis, and chemoresistance and describes new approaches to designing galectin inhibitors. This is a core reference for chemists, biochemists, pharmacologists, biologists, and others interested in this emerging field.

Aus dem Klappentext

The comprehensive guide to the current understanding of galectins and their promising potential in drug design

This is the first book focusing on galectins. It was inspired by topics discussed at the symposium "Galectins: Structures, Functions, and Therapeutic Targets" that was a part of the 234th American Chemical Society meeting in 2007. To help chemists, biochemists, and others understand the challenges inherent in the study of galectins and build on recent advances in the field, the editors have compiled articles from leading experts on galectins and their biomedical applications. Galectins includes:

• An overview of early galectin research

• An explanation of the nature of galectins

• A discussion of the structure and functions of galectins, their ligand specificity and molecular mechanisms of action, and the localization of galectins in the cell

• An exploration of the roles galectins play in tumor growth and cancer, fibrosis, inflammation, and immunity

• A discussion of the effect of galectins on cell migration, angiogenesis, and chemoresistance

• An introduction to new approaches to designing galectin inhibitors

This is the premier reference on galectins for organic, medicinal, carbohydrate, and pharmaceutical chemists, biochemists, molecular and cell biologists, pharmacologists, cancer researchers, and graduate-level students in these disciplines, as well as clinicians and drug developers.