Stem Cells: Nuclear Reprogramming and Therapeutic Applications (Novartis Foundation Symposia, Band 265) - Hardcover

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Stem cells are specialized cells with unique potential for self-renewal and specific cell-type commitment. They remain uncommitted until a particular physiological signal prompts them to differentiate and become lineage-specific cells with particular physiological functions.

In 1998 investigators isolated embryonic stem cells from human embryos for the first time and were able to culture these in vitro. Since then, stem cell-based technologies have received enormous scientific attention because of their potential for developing novel therapeutic applications. Potential clinical applications covered in the book include the production of cardiomyocytes to replace damaged heart tissue, the production of insulin-producing cells for patients with diabetes, and the generation of neurons for the treatment of patients with Parkinson’s disease or spinal cord injury.

Particular attention is paid to the factors that maintain stem cells in a pluripotent state or which drive them to create differentiated and lineage-committed cells in vitro and in vivo. Understanding stem cells at the molecular level is essential to understanding their behaviour in a physiological context. Nuclear reprogramming, the process by which a nucleus acquires developmental potential, is currently a focus of great interest in the scientific community and is covered here. It is relevant to stem cell research generally, and also to research on the cloning of animals by nuclear transfer.

The book features animated discussion from the world’s experts in this topic on the important ethical issues that are raised by research on stem cells. They review the various regulatory regimes which apply in different countries―a key factor in determining where future stem cell research is carried out. This book is an essential purchase for all those engaged in stem cell research, whether in the laboratory, the clinic or the regulatory authorities.

Aus dem Klappentext

Stem cells are specialized cells with unique potential for self-renewal and specific cell-type commitment. They remain uncommitted until a particular physiological signal prompts them to differentiate and become lineage-specific cells with particular physiological functions.

In 1998 investigators isolated embryonic stem cells from human embryos for the first time and were able to culture these in vitro.  Since then, stem cell-based technologies have received enormous scientific attention because of their potential for developing novel therapeutic applications. Potential clinical applications covered in the book include the production of cardiomyocytes to replace damaged heart tissue, the production of insulin-producing cells for patients with diabetes, and the generation of neurons for the treatment of patients with Parkinson’s disease or spinal cord injury.

Particular attention is paid to the factors that maintain stem cells in a pluripotent state or which drive them to create differentiated and lineage-committed cells in vitro and in vivo.  Understanding stem cells at the molecular level is essential to understanding their behaviour in a physiological context. Nuclear reprogramming, the process by which a nucleus acquires developmental potential, is currently a focus of great interest in the scientific community and is covered here. It is relevant to stem cell research generally, and also to research on the cloning of animals by nuclear transfer. 

The book features animated discussion from the world’s experts in this topic on the important ethical issues that are raised by research on stem cells. They review the various regulatory regimes which apply in different countries―a key factor in determining where future stem cell research is carried out. This book is an essential purchase for all those engaged in stem cell research, whether in the laboratory, the clinic or the regulatory authorities.