Reagents for Direct Functionalization of C–H Bonds (Handbook of Reagents for Organic Synthesis) - Hardcover

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Professor Philip L. Fuchs, Department of Chemistry, Purdue University, IN He began his career at Purdue in 1973. Since that time, he has graduated an extended family of 55 Ph.D.s. His awards and honors include an Eli Lilly young faculty fellowship (1975), an Alfred P. Sloan fellowship (1977), a Pioneer in Laboratory Robotics award (1986), a Martin teaching award (1991), and being voted by the students as one of Top 10 Teachers in School of Science at Purdue (1991, 1993, 1995, 1996). Fuchs has consulted for Pfizer, and Eli Lilly, served on the editorial board of The Journal of Organic Chemistry, and is currently an executive editor for the Electronic Encyclopedia of Organic Reagents (e-EROS), an online dynamic encyclopedia published by John Wiley & Sons.

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Syntheses requiring high material throughput are made even more challenging when targeting pure enantiomers. Asymmetric reactions employing chiral catalysts and prochiral substrates are highly attractive because one molecule of catalyst generates a multitude of chiral progeny. Modern synthesis is rapidly evolving by creating new transformations that employ C-H bonds as the locus for specific functionalization. This Handbook presents short, informative articles on some 80 reagents that summarize the current state-of-the-art using chiral strategies efficiently to increase molecular complexity. These transformations include arene and heteroarene functionalizations, the introduction of heteroatoms, the formation of chiral centers, rings and multiple bonds, and enantiogenesis.

All the information compiled in this volume is also available in electronic format on Wiley InterScience. The electronic Encyclopedia of reagents for Organic Synthesis (e-EROS)) includes all the reagents described here plus many more reagents of other types and for other uses. e-EROS offers text and structure search and is updated twice a year. For More information visit: http://www.mrw.interscience.wiley.com/eros/