Imaging Blood-Brain Barrier Dysfunction in Brain Disorders - Softcover

Über die Autorinnen und Autoren

Dr. Danny JJ Wang is currently the Professor of Neurology and Radiology, and Director of Imaging Technology Innovation at the Stevens Neuroimaging and Informatics institute, Keck School of Medicine at USC, as well as head of the Laboratory of Functional MRI Technology (LOFT). During the past 25 years, his research has been focused on the technical development and clinical translations of novel functional and physiological MRI technologies. He is a recognized expert in perfusion and functional MRI and has extensive experience in clinical applications related to cerebrovascular disorders, dementia and neurodevelopment. Dr. Wang was elected Senior Fellow of the ISMRM in 2022.

Dr. Xingfeng Shao is an Assistant Professor of Radiology at USC Stevens Neuroimaging and Informatics institute, Keck School of Medicine at USC. His research focuses on the development and applications of innovative MR image acquisition in normal and diseased populations, particularly in perfusion MRI, laminar ASL fMRI at ultra-high field and blood-brain barrier (BBB) function. Dr. Shao been actively participating international MRI societies and received prestigious awards such as the ISMRM I.I. Rabi Young Investigator finalist (2023), ISMRM W.S. Moore Young Investigator finalist (2018), ISMRM Junior Fellow, OCSMRM young investigator award and ISNVD young investigator award.

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The blood-brain barrier (BBB) plays a critical role in the delivery of oxygen and nutrients to the brain, the clearance of toxic metabolites, and protection of the central nervous system (CNS) from infection. Compromised or impaired BBB function is implicated in a number of serious brain diseases, such as multiple sclerosis, stroke, brain tumors, traumatic brain injury (TBI), cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). Emerging medical imaging technologies, in particular magnetic resonance imaging (MRI), have allowed in vivo imaging of natural variation of BBB function with aging and during sleep, as well as BBB dysfunction in a range of brain disorders with high socioeconomic impact. Imaging Blood-Brain Barrier Dysfunction in Brain Disorders introduces the structure and function of the BBB, its role in the pathogenesis of brain disorders, and state-of-the-art medical imaging technologies for imaging BBB function in both the healthy and diseased brain.

With this book the reader will learn: The structure and function of the blood-brain barrier (BBB); The role of BBB in maintaining normal brain function (e.g. aging and sleep); The type of BBB aberrations in brain disorders - stroke, traumatic brain injury, cerebral small vessel disease, Alzheimer's disease, and sleep apnea; Modern medical imaging technologies (e.g. MRI) for in vivo imaging of BBB function in both the healthy and diseased brain; How imaging of BBB can help monitor and cure brain disorders; The potential of BBB imaging in early detection of neurological disorders, facilitating timely and effective treatment strategies.