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New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management - Softcover
Inhaltsangabe
New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management provides crucial insights for developing ideal synthetic opioids. It discusses opioid receptor modulators’ structures and mechanisms, and their potential applications in treating pain, misuse, and addiction. This comprehensive resource delves into current research and therapeutic development avenues regarding opioid receptors' structure and function. Sections cover the rationale for developing allosteric modulators, identifying allosteric sites on opioid receptors, and the modulators' modes of action. Readers will gain a thorough understanding of creating ideal synthetic opioids and potential future research.
It also explores pharmacogenomics, precision medicine, and various syndromes and comorbidities linked to opioid use. Lastly, it reviews novel synthetic opioids and the risks of misuse and overdose.
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Über die Autorinnen und Autoren
Dr. Kaye has been a practicing physician scientist for over 30 years. He is Vice Chancellor of Academic Affairs at LSU Health Shreveport. It has been a personal goal of his to significantly contribute to the education and development of future physicians, scientists, professors, and researchers. Dr. Kaye’s laboratory has made significant scientific contributions through in vivo, prospective human clinical trials, and retrospective data review research involving anesthesiology airway devices, multimodal pain management, and novel pharmaceuticals. In 2022 he has contributed to 12 books, 44 book chapters, and 144 PubMed articles, all of which include students, residents, and faculty, and involve collaborations from different departments at LSU. Overall, he has published over 1000 PubMed articles and has authored/co-authored over 300 abstracts. Dr. Kaye has mentored hundreds of clinical fellows, residents, and faculty appointments, in addition to hundreds of medical and graduate students.
Dr. Edwards received his PhD in the Departments of Neuroscience and Psychiatry at the University of Texas Southwestern Medical Center with support from the National Institute on Drug Abuse (NIDA). Afterwards, he joined the Committee on the Neurobiology of Addictive Disorders at The Scripps Research Institute where he was awarded a K99/R00 Pathway to Independence award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Dr. Edwards joined the Department of Physiology at LSU Health New Orleans in 2013 and is a member of the NIAAA-funded P60 Comprehensive Alcohol-HIV/AIDS Research Center and Alcohol & Drug Abuse Center of Excellence. His preclinical and translational research examines neurobiological interactions between chronic pain and substance use disorders.
Von der hinteren Coverseite
New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management is indispensable for anyone interested in development of an ideal synthetic opioid. It offers a thorough discussion of the structures and mechanisms of opioid receptor modulators’ actions, and the potential applications of these molecules in the treatment of pain, opioid misuse, and addiction. It encompasses current research and therapeutic development avenues with respect to the structure and function of opioid receptors. Readers will gain a comprehensive understanding of the development of an ideal synthetic opioid, as well as the potential for future research and development. New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management provides a comprehensive overview of the opioid receptor system and novel aspects of opioid pharmacology. It covers the rationale and potential of the development of allosteric modulators for opioid receptors, identification of potential allosteric sites on opioid receptors, and modes of action of the modulators. It also discusses pharmacogenomics and precision medicine as they relate to opioid-related interactions and metabolism considerations, and various syndromes and comorbidities associated with opioid use. Finally, it reviews categories of novel synthetic opioids and the associated risks of misuse and overdose.
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