Essentials of Pharmatoxicology in Drug Research, Volume 1: Toxicity and Toxicodynamics (Advances in Pharmaceutical Product Development and Research) - Softcover

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Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

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Toxicity and Toxicodynamics in Drug Research, Volume 1: Essentials in Pharmatoxicology provides an overview on the essentials of toxicology, risk assessment, and the mechanisms that might occur as the result of toxicological and the potentially harmful action and response of pharmaceuticals.

Volume 1: Essentials in Pharmatoxicology opens with an introduction to pharmatoxicology and toxicology in drug research. It covers topics such as the types of cellular responses to chemical toxicants, the mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology. The book also covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as expounds on the role of regulatory agencies in toxicity studies. It covers the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. There is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.