Neurotoxicity of Halogenated Organic Compounds: Volume 10 (Advances in Neurotoxicology, Volume 10) - Hardcover

Über die Autorinnen und Autoren

Dr. Lucio G. Costa is Professor of Toxicology at the University of Washington in Seattle, and of Pharmacology/Toxicology at the University of Parma Medical School. He received a doctorate in Pharmacology from the University of Milano in 1977, and was a postdoctoral fellow at the University of Texas at Houston. He is a member of several national and international professional organizations, a Fellow of the Academy of Toxicological Sciences, and a European Certified Toxicologist. He received various award for his scientific accomplishments, including the Achievement Award from the Society of Toxicology. He serves in various editorial capacities for several toxicology journals, and is an active manuscript and grant reviewer. Dr. Costa has been the member of dozens of panels and committees at the national and international level dealing with toxicology and risk assessment issues. He has chaired and/or organized symposia at scientific meetings in the United States and internationally. He has been teaching classes in the area of toxicology, neurotoxicology and pharmacology to graduate and medical students for 30 years. He keeps an active research program in the area of neurotoxicology.

Dr. Michael Aschner is currently the Harold and Muriel Block Chair in Molecular Pharmacology at Albert Einstein College of Medicine where he is also a Professor in the Departments of Molecular Pharmacology, Neuroscience, and Pediatrics. He is a leading expert in neurotoxicology and neurodevelopmental and neurodegenerative diseases. In addition to serving as a past president of the Society of Toxicology (2022-23), he served on numerous toxicology panels (U.S. EPA and CDC), been an expert reviewer for multiple federal agencies in the US and abroad, and is a member of the Neurotoxicology and Alcohol study section (NIH). He is a past recipient of the prestigious Society of Toxicology Merit Award (2010) and the Distinguished Neurotoxicologist Award (2020). He is a co-editor of the Elsevier series, Advancements in Neurotoxicology in addition to edited other Elsevier titles. He has published numerous articles and has served as an associate editor for multiple high impact factor journals.

Dr. Prasada Kodavanti is a Senior Research Toxicologist at the Neurological & Endocrine toxicology branch of Public Health & Integrated Toxicology Division at CPHEA/ORD, U.S. Environmental Protection Agency in Research Triangle Park, NC, USA. In this role, he leads a team of scientists to develop in vitro models based on adverse outcome pathways (AOPs) and O’mics technology in New Approach Methods (NAMs) by selecting a few chemicals for initial testing. The goal is to develop efficient NAMs based on O’mics for screening and prioritization of untested chemicals and also provide scientific support for the existing NAMs such as neurite outgrowth and microelectrode array assays. He also plays a key role in the Safe and Healthy Communities project related to understanding the interaction between chemical stressors and non-chemical factors and develop genomic biomarkers in blood to identify vulnerable communities. He joined the USEPA as a Toxicologist in January of 1995. Dr. Kodavanti is a recognized scientist internationally in the area of halogenated organic compounds and adult/developmental neurotoxicity. Dr. Kodavanti is an extremely prolific researcher with over 125 peer-reviewed journal articles. In addition, he is primary author on 26 book chapters as well as 8 review articles. His publications appear in a wide variety of leading scientific journals and is well quoted by scientists in this field. In 1996, one of his papers won the prestigious Society of Toxicology’s Board of Publications Award for the Best Paper in Toxicology and Applied Pharmacology. He received USEPA’s 1996, 1999, 2002, and 2012 Scientific and Technological Achievement (STAA) Award. In 2009, he received STAA level 1 award (highest scientific award by USEPA) for highlighting genomics in understanding mode of action in developmental neurotoxicity. Dr. Kodavanti gave several invited presentations at national and international meetings. Dr. Kodavanti served as session chair in several conferences and a member of Special session organizing committee of the Dioxin ’97. He is a member of the Advisory Board for several journals and current ones include “The Open Toxicology” and “Neurotoxicology”. He was an Associate Editor for the journal “Drug and Chemical Toxicology”. Dr. Kodavanti is also an Adjunct Professor of Toxicology, School of Pharmacy at University of Rhode Island, Kingston, RI since April 2000. He is also a reviewer for a number of International scientific journals.

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During the past century, Halogenated Organic Compounds have been used widely in industrial, agricultural, and consumer products as well as other applications. This extensive use and persistence of these compounds in the environment resulted in global contamination that affects g human health by causing low birthweights, learning and memory deficits, psychomotor changes, and neuroendocrine effects. This volume highlights the Neurotoxicity of Halogenated Organic Compounds, a topic of current interest to several scientists throughout the global community. Three groups of Halogenated Organic Compounds (Chlorinated, Brominated, and Fluorinated Compounds) that are legacy and emerging contaminants are the focus of this volume. Initially, critical information about these three groups of chemicals were discussed by providing background information, characteristics, physicochemical properties, environmental contamination, and human exposure. Next, for each group of chemicals, the following was addressed: Neurotoxic effects (including epidemiological and animal studies); Neuroendocrine effects (significant effects such as drop in thyroid hormones etc); Neurochemical effects discussing mode of action; were included as separate chapters. Finally, future directions and regulatory aspects related to these compounds were discussed.