Receptor - Based Drug Design (Drugs and the Pharmaceutical Sciences) - Softcover

9780367400521: Receptor - Based Drug Design (Drugs and the Pharmaceutical Sciences)

Softcover

ISBN 10: 0367400529 ISBN 13: 9780367400521

Verlag: CRC Press, 2019

Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design.
Explains the experimental and theoretical methods used to characterize interactions between ligands and receptors-providing the pharmacological information needed to solve treatment problems and facilitate the drug design process!
Demonstrating the achievements of the receptor-based approach in therapeutics and indicating future directions, Receptor-Based Drug Design

introduces novel computer-assisted strategies for the design of new agonists, antagonists, and inverse agonists for G-protein-coupled receptors

shows how to assess agonist concentration-effect curve data

discusses radioligand binding assays

presents new in vitro multiarray assays for G-protein-coupled receptors

explains the use of individual second messenger signaling responses in analyzing drug-receptor interactions

examines the role of electrophysiology in finding new drugs and drug targets

describes selectively acting b-adrenoceptor agonists and glucocorticoid steroids for asthma treatment

outlines the rationale for using angiotensin receptor antagonists

and more!
Written by over 25 international authorities and containing nearly 1200 bibliographic citations, Receptor-Based Drug Design is a practical resource for pharmacologists, pharmacists, and pharmaceutical scientists; organic and medicinal chemists and biochemists; molecular biologists; biomedical researchers; and upper-level undergraduate and graduate students in these disciplines.

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�ber die Autorin bzw. den Autor

Leff Paul

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Verlag: CRC Press
Erscheinungsdatum: 2019
Sprache: Englisch
ISBN 10: 0367400529
ISBN 13: 9780367400521
Einband: Taschenbuch
Anzahl der Seiten: 400
Herausgeber: Leff Paul
Kontakt zum Hersteller: preigu GmbH & Co. KG
mail@preigu.de

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