Phage Therapy - Part B: Volume 201 (Progress in Molecular Biology and Translational Science, Volume 201) - Hardcover

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Prof. Vijai Singh is currently serving as Head of the Department of Biosciences, School of Science and Dean (Research & Innovation) at Indrashil University, Rajpur, Mehsana, India. Prior to this, he held the position of Associate Professor in the same department at Indrashil University. He has also served as Assistant Professor in the Department of Biological Sciences and Biotechnology at the Institute of Advanced Research, Gandhinagar, and in the Department of Biotechnology at the Invertis University, Bareilly, India. Earlier of his career, Prof. Singh worked as a Postdoctoral Fellow in the Synthetic Biology Group at the Institute of Systems and Synthetic Biology, Paris, France and at the School of Energy & Chemical Engineering at the Ulsan National Institute of Science and Technology, Ulsan, South Korea. He earned his Ph.D. in Biotechnology in 2009 from the ICAR-National Bureau of Fish Genetic Resources, Uttar Pradesh Technical University, Lucknow, India. His doctoral research focused on the development of molecular and immunoassays for the diagnosis of Aeromonas hydrophila. Prof. Singh’s research interests lies in the design and construction of novel biosynthetic pathways for production of medically and industrially important biomolecules. His laboratory is also actively engaged in developing CRISPR-Cas systems for gene knock out, knock in, gene regulation and diagnostic. With over 15 years of research and teaching experience, his areas of expertise include synthetic biology, metabolic engineering, bioinformatics, microbiology, and industrial microbiology. He has an extensive academic record, with over 110 articles, 89 book chapters, 26 books and 3 patents to his credits. Prof. Singh has received number of prestigious awards, including the Bioclues Innovation, Research and Development Award (2023) from the BIOCLUES Society, the Vice Chancellor's Best Research Award (2023) from Indrashil University, and the Agathiyar Chemical Biology Award (2023) from the Society of Chemical and Synthetic Biology. At Indrashil University, he currently serves as chairman of the Board of Study, and is a member of the Academic Council of Indrashil University. He also holds the position of the Member Secretary of the Institutional Biosafety Committee (IBSC) at the university. Dr. Singh is actively involved in national and international scientific advisory roles.

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Bacteriophages (or phages) are ubiquitous in nature and the most abundant biological entities on our planet. It is a natural enemies of bacteria. Phages are obligate intracellular parasites and replicate inside the host either lysogenic or lytic mode after infection using the cellular machinery of a bacterium. On the basis of their anti-bacterial property and unique characteristics, phages are being comprehensively evaluated taxonomically. The accumulating genome sequences data of various phages are being provided an opportunity to researchers to annotate and characterise the various putative gene candidates to understand the molecular mechanisms involve in the lytic and lysogenic states.

This volume offers phage for treatment of number of bacterial pathogens such as Pseudomonas aeruginosa, Vibrio cholera, Mycobacterium species, phage for treating gut microbiome and phage uses as delivery systems. Phage also uses for detection of disease, phage display, use as carriers for loaded with drug, phage for precise drug delivery to treating disease, improving phage fitness and performance using genome editing technology. This volume also offers use of the phage for treating cancer and regenerative medicine as well as use in the cosmetics. This volume is an excellent source of information with enriched text on phage and their use for treatment of bacterial infections. This volume highlights a number of aspects of the phage in a way that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.