Genetic Immunization - Hardcover

Bot, Adrian; Bona, Constantin A.

 
9780306462269: Genetic Immunization
Hardcover
ISBN 10: 0306462265 ISBN 13: 9780306462269
Verlag: Springer, 2000

Inhaltsangabe

Wolf’s discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto­ immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.

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Reseña del editor

Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto­ immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.

Reseña del editor

This book presents the critical information attendant to developing vaccines using the genetic basis of immunology. The authors explore which techniques and experimental paths can be pursued so that efficacious results in human trials can be reasonably expected for the treatment of bacterial, fungal, viral, and autoimmune diseases, as well as cancers. A chapter on the genetic vaccination of neonates with virus or plasmid DNA is also included.

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Verlag
Springer
Erscheinungsdatum
2000
Sprache
Englisch
ISBN 10 
0306462265
ISBN 13 
9780306462269
Einband
Tapa dura
Anzahl der Seiten
200
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Deutschland

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