Perspectives on Biologically Based Cancer Risk Assessment: 23 (Nato Challenges of Modern Society) - Hardcover

Luebeck, E. Georg; Zapponi, Giovanni A.

 
9780306461088: Perspectives on Biologically Based Cancer Risk Assessment: 23 (Nato Challenges of Modern Society)
Hardcover
ISBN 10: 0306461080 ISBN 13: 9780306461088
Verlag: Springer, 1999

Inhaltsangabe

The first meeting of the NATO/CCMS Pilot Study "Dose-Response Analysis and Biologically-Based Risk assessment for Initiator and Promoter Carcinogens" was held in Rome, Italy, in the spring of 1991, and was followed by annual or bi-annual meetings held in Germany, Greece, Netherlands, Portugal, USA, up to the end of 1995; in large part supported by NATO/CCMS grants or fellowships, and organized by Pilot Study participants. The Pilot Study activity has been characterized by a higly collaborative atmosphere, which was essential for a deep and detailed analysis of a problem on which different points of view, methodological approaches and regulations exist in the various member countries. The Pilot Study was aimed at proposing a carcinogenic risk assessment procedure which is based on a detailed analysis of the relevant biological processes, and may also consent the verification of hypotheses. The specific form of theoretical and mathe­ matical models is identified by considering and using the whole set of objective data available. The multidisciplinary approach of the pilot study is reflected by the struc­ ture of this book. Each chapter is the result of the cooperation of several authors from to produce a comprehensive manual that includes different countries; its objective was both theoretical and practical information.

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Reseña del editor

The first meeting of the NATO/CCMS Pilot Study "Dose-Response Analysis and Biologically-Based Risk assessment for Initiator and Promoter Carcinogens" was held in Rome, Italy, in the spring of 1991, and was followed by annual or bi-annual meetings held in Germany, Greece, Netherlands, Portugal, USA, up to the end of 1995; in large part supported by NATO/CCMS grants or fellowships, and organized by Pilot Study participants. The Pilot Study activity has been characterized by a higly collaborative atmosphere, which was essential for a deep and detailed analysis of a problem on which different points of view, methodological approaches and regulations exist in the various member countries. The Pilot Study was aimed at proposing a carcinogenic risk assessment procedure which is based on a detailed analysis of the relevant biological processes, and may also consent the verification of hypotheses. The specific form of theoretical and mathe­ matical models is identified by considering and using the whole set of objective data available. The multidisciplinary approach of the pilot study is reflected by the struc­ ture of this book. Each chapter is the result of the cooperation of several authors from to produce a comprehensive manual that includes different countries; its objective was both theoretical and practical information.

Reseña del editor

The book includes a comprehensive updated analysis of cancer risk assessment procedures, with particular attention to biologically-based modelling. The presented arguments include the basic assumptions of cancer risk assessment methods, their biological basis and theoretical background, the relevant data sources, the multistage models (including the two-stage and clonal expansion models and pharmacokinetic models), and the relevant biomarkers, together with fundamental statistical considerations and selected case studies and examples of practical applications. The uncertainty of assessment and the practical use of the proposed methods are also discussed and possible new developments suggested. The book examines in detail the updated biologically-based carcinogenic risk assessment procedures together with the usually employed procedures, as well as background information on which they are based. It also proposes new ideas and methods in this field. Furthermore, it includes criteria and methods for practical application and use of the examined procedures.

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Verlag
Springer
Erscheinungsdatum
1999
Sprache
Englisch
ISBN 10 
0306461080
ISBN 13 
9780306461088
Einband
Tapa dura
Anzahl der Seiten
336
Herausgeber
Cogliano Vincent James
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Deutschland

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